ABSTRACT
Objective To investigate the changes of serum adipocyte fatty acid binding protein (A-FABP) and high sensitivity C reactive protein(hs-CRP) in patients with acute ischemic stroke .Methods The total of 116 patients with acute ischemic stroke and 80 synchronously examined healthy people(controls) were collected .The levels of hs-CRP and A-FABP were detected by double-antibody sandwich enzyme linked immunosorbent assay (DAS-ELISA) in all the subjects .Stroke severity were scored by modified Rankin Scale (mRS) .The patients with acute ischemic stroke were divided into the light (mRS≤3) and the severe group(mRS>3) .Changes of the level of hs-CRP and A-FABP were compared in two groups .Linear correlation and regression analysis were per-formed to hs-CRP and A-FABP .Results The levels of serum hs-CRP and A-FABP were significantly higher in acute ischemic stroke group than those in the control group .The severer the neurologic impairment degree was in the patients with acute ischemic stroke ,the higher the levels of serum hs-CRP and A-FABP .Linear correlation and regression analysis results showed that the level of A-FABP was significantly positively correlated with the level of hs-CRP .Conclusion The levels of serum hs-CRP and A-FABP is associated with acute ischemic stroke .The level of A-FABP is significantly positively correlated with the level of hs-CRP .The hs-CRP and A-FABP may have an action in occurrence and development of acute ischemic stroke .
ABSTRACT
Objective To explore the relationship between interleukin-18(IL-18)and cardiovascular risk factors in patients with systemic lupus erythematosus(SLE).Methods A total of 59 female SLE patients were divided into three groups,according to the IL-18 concentration:≤200 pg/mL(group A),>200-350 pg/mL(group B),>350 pg/mL(group C).The cardiovascular risk fac-tors including body mass index(BMI),systolic blood pressure,diastolic blood pressure(DBP),fasting insulin and glucose,blood lip-id,brachial-ankle pulse wave velocity(baPWV),and plasma homocysteine(Hcy)were determined in all patients.Results Compared with group A patients whose plasma IL-18 level was the lowest,the levels of insulin,triglyceride,Hcy and values of homeostasis model assessment insulin resistance(HOMA-IR)were significantly higher in SLE patients of group C,whose plasma IL-18 level was the highest(P <0.05).Conclusion In patients with SLE,the synergistic effects of hyperinsulinaemia,insulin resistance,hyper-homocysteinaemia,and vascular stiffness most likely contribute to the elevation of plasma IL-18 concentrations.