ABSTRACT
Background and Objective: Chronic obstructive pulmonary disease [COPD] is characterized by chronic incompletely reversible poor airflow and air trapping and usually this debilitating disorder limits the outside activities of the patients depriving them of sunlight which is a rich source of Vitamin D. The objective of this study was to determine the effect of vitamin D supplementation in reducing number of acute exacerbation in COPD patients
Methods: This randomized control trial was conducted at East Medical Ward Mayo Hospital Lahore from January to December 2015 as exacerbations of COPD are season dependent. Diagnosis was confirmed by performing Pulmonary Function Tests [PFTs]. Basic demographical information was obtained and baseline PFTs of the patient was done. Only Group A patients was treated with oral vitamin D intake of 2000 IU daily for 6 months. Vitamin D level was measured at 0, 2, 4, and 6 months and exacerbation of COPD, FEV1 and FVC was measured weekly. Both the groups were given standard treatment for exacerbation of COPD. Spirometry was repeated at each visit. Blood samples were collected every 2 months for vitamin D. Supplementation was stopped if vitamin D level exceeded 100ng/ml
Results: The mean age of the patients was 46.28 +/- 8.83 years, the male to female ratio was 1.8:1. The mean 25[OH] level at baseline was 24.08 +/- 2.58 and at 6th month was 29.60 +/- 8.74. The mean FVC at baseline was 77.83 +/- 5.49 and at 6th month was 91.34 +/- 5.52. The exacerbation at baseline was present in all 120[100%] patients and at 6th month was reduced to 4[3.3%]
Conclusion: Vitamin D supplementation has significant effect in reducing number of acute exacerbation in COPD patients when it is given for prolonged period
ABSTRACT
Objective: To study the effect of Vitamin D supplementation on reduction in level of HbA1 in patients recently diagnosed with diabetes mellitus Type II having asymptomatic Vitamin D deficiency
Methods: This randomized control trial was conducted at East Medical Ward Mayo Hospital Lahore for 6 months from January 01 2016 to June 30, 2016. 114 Patients were included through non probability purposive sampling technique. Informed consent and demographic information was collected. Patients were divided in two groups by randomization through tossing a coin. GroupA patients received Metformin tablet alone at 500 mg after dinner and Group-B patients were treated with same dosage of Metformin along with oral vitamin D at 200,000 ILJ monthly for three months. Blood sample was obtained at baseline, 3 months and 6 months of initiation of therapy. All samples were sent to the laboratory for complete blood count, blood sugar fasting, serum calcium, serum phosphorous, serum alkaline phosphatase, HbA1c and serum 25 Hyroxy Vitamin D [S-25[OH] D] levels and iPTH. Data entry and analysis was done by using SPSS 20
Results: The mean age of patients in metformin group was 42.37+/-4.59 years while mean age of patients in combination group was 43.33+/-4.86years. Males were 45.6% and females were 54.4% in metformin group while in combination group, 36.8% were males1 and 63.2% were females'. At baseline, in metformin group, mean Vitamin D level was 17.09+/-1.73mg/dl and in combination group, mean Vitamin D level was 16.49+/-n D was 29.04+/-3.96mg/dl. At baseline, 1[st] and 2[nd] visit, in metformin group, mean HbA1c was 7.59+/-0.47%, 7.46+/-0.25% and 7.30+/-0.29%. At baseline, 1[st] and 2[nd] visit, in combination group, mean HbA1c was 7.71 +/-0.19%, 7.57+/-0.21% and 7.43+/-0.26%. The difference was insignificant [p>0.05] at baseline while significant on later follow-ups [P<0.05]
Conclusion: Vitamin D supplementation improved the glycemic control but substantial reduction in HbA1c was statistically insignificant in both groups
Subject(s)
Humans , Female , Male , Adult , Middle Aged , Vitamin D/physiology , Glycated Hemoglobin , Metformin , Vitamin D DeficiencyABSTRACT
Abstract: To establish the role of anti H. pylori eradication therapy in alleviation of symptoms in H. pylori positive non-ulcer dyspepsia [MUD] patients
Material and Methods: This clinical trial was carried out in the Medical unit II and Medical Special unit of the Services Hospital, Lahore during the period from 2003 to 2004.100 patients with the symptoms of dyspepsia without having evidence of peptic ulcer on upper Gl endoscopy were included in the study. Out of these 100 patients 33 were found H. pylori negative on first endoscopy and histopathology, whereas, the remaining number of 67 was completed by confirmation of H. pylori eradication in initially positive cases. Post treatment six weeks follow up was performed to confirm outcome
Results: The H. pylori eradication therapy did not show statistically significant improvement in symptoms of NUD patients
Conclusion: Routine H. pylori eradication has little role in the alleviation of symptoms in patients with NUD