ABSTRACT
Obstructive sleep apnea (OSA) is associated with significant cardiovascular and cerebrovascular morbidity and mortality. Usual parameters studied in sleep laboratory are unable to measure overall impact of OSA on human life. Consequently, it is important to measure Quality of Life (QoL) in OSA. QoL can be measured with generic instruments like SF-36 or OSA specific questionnaires like Calgary Sleep Apnea Quality of Life (SAQLI) questionnaire. Most of the studies suggest that there is significant impairment of QoL in patients of OSA. But the present evidence suggests that impairment in QoL is not proportional to severity of OSA. There is no consensus on the question of improvement in QoL with Continuous Positive Airway Pressure (CPAP) therapy. A recent Cochrane review concluded that CPAP improves QoL in people with moderate and severe OSA.
ABSTRACT
We present a case of a 48-year-old male who was diagnosed and treated for Wegener’s granulomatosis on the basis of history, clinical features, computed tomography (CT) and antineutrophil cytoplasmic antibodies (ANCA) positivity. The patient initially improved and later on during course of the disease he was found to be human immunodeficiency virus (HIV) seropositive. The potential pitfalls of cANCA in a HIV-infected patient are discussed.