ABSTRACT
Introduction: thalasemia Major is one of the most common anemia diseases that can be fatal if not promptly diagnosed. The survival analysis of these patients can be an appropriate strategy in determining risk factors for death in these patients. The purpose of this study was to choose the best model to determine the risk factors for death in patients with the thalasemia major using common methods in the survival analysis
Methods: the data of this retrospective cohort study, with 296 patients with thalassemia major, was collected in 2004- 2013 in Zafar Clinic in Tehran. Akaicke information Criterion was used for comparison of the models and the choice 351of the best model. Data analysis was carried out with R3.0.2 software at the significant level of 0.1
Results: the values of the Akaicke information criterion [AIC] for the parametric weibull, frailty weibull, log-normal, log-logistic, Gompertz, gamma and the semiparametric Cox were computed and found to be 27.56, 29.56, 18.73, 23.39, 26.26, 68.10, 24.73, respectively. The mean survival time for men and women were 40.2 and 39.7 years, respectively. The Log-normal model showed that age, age at the first desferal injection, onset of blood injection, the patient's birthplace, mother's education variables were significantly correlated with patient survival
Conclusion: according to the values of AIC, the parametric log-normal model was chosen and suggested as the best model
ABSTRACT
In 21[st] century obesity has rapidly increased and it has become one of the greatest public health problems worldwide. The aim of this study was to determine related factors with obesity in Tehranian households. In this descriptive study, multivariate analysis was used to estimate the odds of obesity [BMI >/= 30 kg/m2] as a function of age, sex, marital status, educational level and smoking by using data from" Tehran Lipid and Glucose Study [TLGS]" database. In this study 3,935 households participants who were equal or more than 20 years old, were recruited from phase III [2006-2008] of this study. Height of participants was measured to the nearest 5 mm without considering their shoe heels. Weight and height were measured using digital electric scale and meter tape. Data were analyzed by SPSS/16 and SAS version 9.1. The mean BMI was 26.59 [kg/m[2]] in men and 27.96 [kg/m[2]] in women. After adjustment for other variables, obesity odds ratios were 1.01 [P<0.001], 2.10 [P<0.001], and 1.54 [P<0.001] for age, women and married individuals, respectively. There was an inverse significant association between education and obesity. Obesity ORS were 0.83 [P<0.028] for high school and 0.50 [P<0.001] for university educational levels. The results of this study show that related factors in this research are similar to other countries. Therefore, obesity with related factors should be considered in health programming
Subject(s)
Humans , Male , Female , Family Characteristics , Body Mass Index , Cross-Sectional Studies , Odds RatioABSTRACT
Background: To identify the prevalence of polypharmacy [concurrent use of 5 or more medications] and the most frequent medications and medication groups used by the elderly residents of Kahrizak Charity Foundation [KCF]
Materials and Methods: This is a descriptive cross-sectional study of 237 elderly residents of KCF [134 female], aged 60 or more, who have been taking care since the spring of 2010. A randomized cluster sampling was done. Polypharmacy was defined as concurrent use of 5 or more medications, prescribed or non-prescribed, excluding locally effective and [PRN] drugs. Classification of medication groups was based on the Anatomical Therapeutic Chemical [ATC] system. The SPSS software was applied for descriptive analysis
Results: Mean number of drugs used for any resident was 5.10 [ +/- 3.22]. Prevalence of polypharmacy was 52.3%. The most frequent used medications among attendants were Calcium- Vit.D, Nitrocantin [Glyceryl Trinitrate], and Atenolol, and in polypharmacy group were Calcium-Vit.D, Nitrocantin, and Aspirin. The most frequent medication groups used by both, the attendants and polypharmacy groups, were Cardiovascular drugs, Nervous system drugs, and Alimentary/Metabolism drugs
Results: The mean number of drugs used for any resident and prevalence of polypharmacy was high among the elderly residents of KCF
Conclusion: More pharmaco-epidemiological studies should be conducted to assess drug use status in Iranian elderly people, specially nursing homes residents, and guidelines should be presented for decreasing the incidence and prevalence of polypharmacy in this population