ABSTRACT
In our experimental study, 48 rats were divided into six groups in a randomized manner: A[1-3] and B [1-3] groups. A1 and B1 were negative controls. Laparotomy was performed and peritoneal inflammation on exposed bowel and peritoneum in A [1-3] and experimental infection induced in peritoneal cavity of B [1-3]. Each rat of A2 and B2 received 100 IU intraperitoneal standard heparin and each rat of A3 and B3 received 100 IU intraperitoneal dalteparin. On the 21
t postoperative day, rats were euthanized and intensity of intraperitoneal adhesions evaluated macroscopically. The results were analyzed with Chi-Square test. Peritoneal adhesions in experimental groups reduced significantly[p < 0.05] in comparison with controls, but nosignificant differences were seen between experimental groups[p > 0.05]. So, dalteparin and standard heparin are effective in preventing adhesion in infectious and noninfectious peritonitis but nosignificant differences were found between these drugs [p > 0.05]. In brief, regarding to the in vivo beneficial effects of LMWH, dalteparin is more recommended