[Relationship between third tri-mester maternal body mass index with maternal and neonatal complications]

Overweight, obesity and ethnicity are effective factors on pregnancy complications. This study was conducted to determine the relationship between third tri-mester body mass index [BMI] with maternal and neonatal complications. This descriptive analytic study was conducted on 551 pregnant women in third tri-mester with Fars, Sistani and Turkman ethnicities in Sayad Shirazi teaching hospital in Gorgan, north of Iran during 2012. BMI calculated at the time of labor admission and the subjects categorized into three groups of normal / underweight, overweight and obese. The mean of maternal age among Fars, Sistani and Turkman ethnic groups were 26.5 +/- 5.5, 24.6 +/- 5.3 and 26.2 +/- 5.2 years, respectively. The mean of gestational age among Fars, Sistani and Turkman ethnic groups were 38.4 +/- 2.3, 38.6 +/- 2.3 and 37.4 +/- 3.2 weeks, respectively. A significant relationship was found between BMI and cesarean section and labor dystocia in Fars and Sistani ethnic groups, respectively [P<0.05], while no relationship was found between BMI and neonatal complications. Overweight and obesity in Fars ethnicity are at risk of cesarean section and those with Sistani ethnicity are at risk of labor dystocia

[Prevalence of clinical manifestations of pre-menstrual syndrome and pre-menstrual dysphoric disorder among medical students in Gorgan, Iran [2010]]

Due to high prevalence of pre-menstrual syndrome [PMS] and pre-menstrual dysphoric disorder [PMDD] and its effect on the educational, professional activities and familial behaviors, this study was conducted to determine the prevalence of clinical manifestations of pre-menstrual syndrome and pre-menstrual dysphoric disorder in medical students. This descriptive-analytic study was done on 162 female medical students of Golestan University of Medical Sciences in Gorgan, Iran during 2010. Demographic characteristics and PMS and PMDD clinical manifestations questionnaire based on DSM-IV-TR and ACOG criteria was filled for each subject. Mean age and menarche age of subjects was 22.2 +/- 2.5 and 13.3 +/- 1.2 years, respectively. 145 students [89.5%] were single. 57.4% and 22.8% of participants fulfilled the criteria of PMS and PMDD, respectively. The most frequent affective and somatic symptom was lethargy and fatigability [57.4%] followed by sensation of bloating and weight gain [45.7%]. The lowest frequent somatic and affective symptoms were dyspnea [8%] and insomnia [1.2%], respectively. There was significant correlation between the prevalence of PMDD and chronical and menarche age [P<0.05]. Pre-menstrual syndrome is a prevalent disorder in medical students of Golestan University of medical sciences in Iran

Maternal serum zinc deficiency in cases of neural tube defect in Gorgan, north Islamic Republic of Iran

Previous studies have shown a high rate of neural tube defects [NTD] in Gorgan, northern Islamic Republic of Iran. This case-control study during 2003-04 compared serum zinc levels and other variables in 23 mothers of neonates affected with NTD and 36 mothers with normal healthy neonates in Dezyani hospital in Gorgan. Mean serum zinc levels in the case and control groups were 13.43 micromol/L [SD 6.3] and 11.41 micromol/L [SD 6.3] respectively. Zinc deficiency was found in 13 [36.5%] of the cases and 7 [19.4%] of the controls. Logistic regression analysis showed an association between the presence of NTD and zinc deficiency [OR 5.06; 95% CI: 1.51-16.94]

Epidemiology of neural tube defects in northern Iran, 1998-2003

We determined the rates of neural tube defects at a referral hospital in Gorgan, north Islamic Republic of Iran, and the relations of these abnormalities to sex, maternal ethnicity, maternal age and season. During 1998-2003, there were 109 cases among 37 951 births, a prevalence of 28.7 per 10 000 [24.8 and 32.8 per 10 000 among males and females respectively]. The rates in Turkmen, native Fars and Sistani ethnic groups were 40.5, 25.2 and 30.8 per 10 000 respectively. The rates of spina bifida and anencephaly were 16.3 and 11.3 per 10 000 respectively. The rate of affected newborns was highest in mothers aged over 35 years [50.7 per 10 000]. The peak prevalence was in December

[Determine serum zinc level of mothers in neural tube defects in Gorgan]

Introduction: Neural tube defects [NTD] comprise a group of congenital malformation that includes spina bifida, anencephaly and encephalocele. Pervious study has shown that the rate of NTDs is 3.12 per 1000 in Gorgan. Some studies have indicated that Zinc deficiency is one of the causative factors of NTDs

Objective: This study carried out to compare the serum Zinc level in maternal affected NTDs with healthy controls

Materials and methods: This case- control study carried out to compare the serum Zinc level in 23 mothers with affected NTDs newborns and 36 healthy controls in Dezyani Hospital in Gorgan during 2003 by spectrophotometery technique

Results: Zinc deficiency was found in 13[36.5%] of the cases and 7[19.4 %] of the controls. The logistic regression analytic showed the relation between the presence of NTDs with Zinc deficiency [OR=5.06, 95%CI: 1.51-16.99] and drug exposure during 1st trimester in mothers [OR=13.12, 95%CI: 1.31-130.97]

Conclusion: Our findings indicated that maternal Zinc deficiency was thought to be one of the important factors in the NTD etiology

[Epidemiology of cleft lip and cleft palate in Gorgan [1998-2003]]

Cleft lip and palate is one of the most common human congenital craniofacial abnormalities with the side effects of middle-ear infections, hard of hearing, nutritional problems, speaking, and other societal burdens. The objective of this study was to assess the frequency of cleft lip and palate and its relation with sex, ethnic group, paternal and maternal age, consanguineous marriage and season in Gorgan during 6 years. This cross-sectional study was done on 37951 births in Gorgan's Dezyani hospital during 1998-2003. Sex, type of abnormalities, ethnic group, paternal and maternal age, consanguineous marriage, season and date of birth were recorded in questionnaires and data were analyzed by SPSS. The prevalence of cleft lip and cleft palate was 0.97 per 1000 birth and it was more common in males [1.08 per 1000] than in females [0.86 per 1000]. The rate of cleft was 0.86, 0.89 and 1.47 per 1000 in native Fars, Turkaman and Sistani ethnic group, respectively. 29.7% of parents had consanguineous marriage. 29.7% of mothers with affected newborns consumed different drugs during pregnancy. The commonest rate was in winter and autumn. Maternal and paternal age was 35.5 and 28.5 years, respectively. Cleft was more common in 1998. This study reveals that incidence of cleft in Gorgan is much closer to European and east Asian countries. Consanguineous marriage and the toxicity of pregnant women with drugs or chemicals can induce cleft palate

[Neural tube defects in newborns and relation with consanguineous marriage, ethnicity and mother's age in Gorgan]

Background and Objective: neural tube defect is one of the most important malformations of the newborns. The aim of this study was to investigate the rates of NTD, anencephaly, spina-bifida cystica, encephalocele and the relation of these abnormalities with sex, ethnicity, mother's age and consanguineous marriage in north of Iran [Gorgan]

Materials and Methods: a cross-sectional study was done on 26280 birth in Dezyani Hospital in Gorgan during 1998-2001

Results: this study has showed that, the NTD rate was 3.08, 2.78 and 3.38 per 1000 in total, males and females, respectively, female to male ratio was 1.31. The rate of spina-bifida, anecephaly and encephalocele were 1.48, 1.48, 0.11 per 1000, respectively. In regard to different races, the rate was 6.78/1000, 4.76/1000 and 2.41/1000 among Turkmans, Systani and native Fars, respectively [P<0.05]. The rate of NTD in the mothers under 20 years was 2.29/1000, in 20-34 years was 3.37/1000 and over 35 years was 2.54/1000. Interstingly, 29.6% of parents with affected newborns had consanguineous marriage

Conclusion: we concluded that there is a higher rate of NTD in this, area, that it might be due to race-ethnicity variations