[Comparison of the analgesic efficacy of odontopaste[R] and a compound with similar formulation as intracanal medicaments]

Different medicaments are used for pain reduction following an emergency endodontic treatment. The aim of this randomized controlled clinical trial was to evaluate the analgesic efficacy of Odontopaste[R] and a corticosteroid-containing compound used as intracanal medicaments in between root canal therapy [RCT] appointments. In this randomized controlled clinical trial, 120 lower first and second mandibular molars with spontaneous pain and sensitivity to percussion were selected and divided into three groups of 40. After root canal preparation, patients were randomly assigned to one of the three groups. Root canals were dressed with Odontopaste in group 1, with an intracanal medicament in group 2 and with placebo in group 3. Patients determined their degree of pain intensity and percussion sensitivity on a Heft-Parker VAS diagram before the first appointment and 24 hours and 7 days post-treatment. Data were analyzed using ANOVA, Tukey's test and Welch test. The mean spontaneous pain and percussion sensitivity scores at 24 hours after the first appointment in groups 1 and 2 were significantly lower than in group 3 [P<0.001]. No statistically significant difference was found between the groups after 7 days neither in spontaneous pain nor in percussion sensitivity. Odontopaste[R] and the intracanal medicament caused a statistically significant reduction in postoperative pain and percussion sensitivity at 24 hours but there was no statistically significant difference at 7 days with the placebo

Characterization and in vitro evaluation of piroxicam suppositories

Piroxicam is an effective anti- inflammatory agent; it is an inhibitor of prostaglandin biosynthesis. The Principal advantage of Piroxicam is its long half-life, which permits the administration of a single daily dose. Piroxicam is approved in the United States for the treatment of rheumatoid arthritis and osteoarthritis. It has been also used in the treatment of Ankylosing Spondylitis, acute musculoskeletal disorders, dysmenorrhoea, postoperative pain and acute gout. Therefore, patients with gastrointestinal disorders or after surgery often have difficulties taking drugs by mouth. Rectal administration may be a good alternative to oral administration in these types of situations. Therefore in the present research work, attempt has been made to formulate piroxicam suppository dosage form in Witepsol base. In the present study, the effectiveness of different agents on dissolution and release rate of piroxicam from its suppository base has been studied. Also, the effect of propylene glycol as cosolvent, polysorbate 80 as increasing solubility and colloidal silicon dioxide as suspending agent on the release behaviour were investigated. Finally, the best formulation was chosen regarding their release profile, the time needed for 75% release of the drug [t[75]], and uniformity of formulations