Lymphocyte subpopulations immunoglobulins A,G and M and complement components C3 and C4 in the type II diabetes

Forty nine type II diabetic patients and 30 controls were studied. Investigations included enumeration of T and B lymphocyte subpopulations and determination of the concentrations of the serum immunoglobulins A. G and M and C[3] and C[4] complement components. A significant reduction in the absolute count of T and B lymphocytes was observed in association with late diabetic complications. A significant rise in IgA concentration was observed in all patients with highest level in association with diabetic nephropathy. C[3] and C[4] complement components were significantly increased in all patients particularly those on oral hypoglycaemic agents with highest values in patients with nephropathy