[Comparison between the effects of ethanolic extract of Artemisia annua and chloroquine on Plasmodium berghei in white mice]

Considering the importance of using native and traditional herbal medicines in the treatment of malaria, we made a comparison between the effects of an ethanolic extract of Artemisia annua and chloroquine on Plasmodium berghei in Sourian mice. In this study 50 Sourian mice were divided into 10 groups, each group consisted of five mice. The evaluation was done according to the Peters test. Nine of ten groups were infected with P. berghei. The first 6 groups were given extracts of Artemisia annua at different concentrations. The seventh and eighth groups received chloroquine and placebo, respectively. The ninth group received no treatment [control group].The tenth group was not infected with Plasmodium berghei and did not receive any treatment and was used for determination of accidental mortality of the mice. In each group, the levels of parasitaemia were determined on the 4[th] and 7[th] days, and compared with those of the control group. To find the most effective concentration, the test was repeated with 55 mice divided into 11 groups using limited spectrum of drug concentrations. We used SPSS software and T-test for data analysis. The results indicated that Artemisia annua extract at the concentrations of 1100 and 1300 mg/kg significantly decreased P. berghei parasitaemia in the infected mice, but at the concentration of 1100 mg/kg Artemisia annua had less toxicity [P<0.05]. According to the results of this study Artemisia annua at the concentration of 1100 mg/kg showed considerable effect on P. berghei

Evaluation of antioxidant activity of methanolic extracts and some fractions of salvia verticillata l. using three different methods

Bradykinin has effects on histaminic response,vessels seepage,cellular reproduction,causing fever, pain and coughs caused by ACE controllers [3,4,6]. Noscapin has controlled Bradykinins contractional effects on guinea pigs trachea and rats vazodofran [5,6]. noscapin stops the secondary effects of eskimi in brains edema, with antagonizing the responses caused by Bradykinin [3,4,8]. considering that opium's alkaloids act as agonist of peptide systems like ankephalins and RAS, its interesting to know the effects of this alkaloids and among them Noscapine on B3 Bradykinin receptors on smooth muscle guinea pig trachea? All variables are reported as mean and standard deviation.We have used pair test and the informations were processed by Excel, Statistical analysis with ANOVA [LSD] SPSS 9. we took diagrams in to consideration and indicated that the contract ional effect of Bradykinin decreased dependent on density, in presence of three different amount of noscapines concentration. In this study we could demonstrate that noscapine interact with Bradykenin as a non competitive antagonist