Formulation and evaluation of sustained resase indomethacin suppositories

The release rate of indomethacin [Ind.] from suppositories formulated with sustained release [SR] granules of drug: polymer: aerosil of different ratios was studied. The release from polyethylene glycol suppositories containing different polycarbophil concentrations was also investigated. The effect of some formulation variables, e.g. aerosil content and molecular weight [MW] of polyethylene glycol, has been evaluated. The major controlling factor appeared to be the drug: polymer ratio for the release from polyvinylacetate [PVAc] and hydroxypropylmethylcellulose [HMPC] polymers. The decrease in aerosil content in SR granules resulted in a decrease in the release rate. As the MW of PEG increased, the release rate decreased. For suppositories containing 5, 10 and 20% of polycarbophil [PC], indomethacin release decreased as PC content increased. The results indicated that these suppositories had a better controlled release of indomethacin than those formulated with either PVAc or HPMC. Different scanning calorimetry [DSC] thermograms showed an interaction between PC and PEG, and also between PEG and indomethacin

effect of particle size and concentration of polycarbophil on its physical properties and the pharmaceutical characteristics of prepared indomethacin tablets

The effect of varying the concentration of polycarbophil and particle size on its physical characteristics viz swelling, flowability and compressibility was investigated. The effect of using polycarbophil, in different concentrations of varying particle sizes, on the characteristics of indomethacin tablets prepared by direct compression was also studied. The swelling of polycarbophil increased as its particle size increased from <0.063 to 1 mm. The particles having particle size range 0.5-0.8, 0.8-1.0 and >1 mm showed excellent flowability. The amount of indomethacin released was found to decrease as the polycarbophil concentration and the particle size increase. The effect of polycarbophil particle size on the dissolution of indomethacin was more pronounced at 5% concentration. 20% polycarbophil, of particle size 0.18-0.8 mm, could be a useful additive in tablet formulation as disintegrant to its bioadhesive character