Synthesis and antimicrobial activities of some quinazolinone derivatives

Using base-catalyzed lossen rearrangement reaction conditions, 3-benzyl-2, 4 quinazolinone [3] was synthesized. It underwent alkylation reactions to give the alkylated products 4 a-g. The hydrazide derivative 5 was used in the synthesis of new derivatives 6-17. All the newly synthesized compounds were tested towards some microorganisms [bacteria and fungi] and some of them were found to have antimicrobial activities. The structures of the new compounds were established from their elemental analysis as well as spectroscopic data

Synthesis and reactions of 2,2'- [m-Phenylene] bis [[4-arylidene-5 [4H] -oxazolones]

2'-[M-phenylene] bis [4-aryliaene-5 [4H]-oxazolones-Va-d have been synthesized. The hydrolysis, alcoholysis, ammonolysis, aminolysis as well as hydrazinolysis of these oxazolones have been studied. When the products of alcoholysis, aminonolysis and aminolysis were heated above their melting points they have eliminated 2 molecules of alcohol, ammonia and amine respectively yielding the starting oxazolones. Also it was noted, that the alcoholysis may be catalyzed by sodium azide. The spectroscopic data by the newly synthesized compounds are discussed. Some of the newly synthesized compounds were tested to determine their dyeing and gmepnti properties