Anticonvulsant activity of some vanilloid receptor agonists

Vanilloid receptors 1 [VR 1], a group of transient receptor potential channels family was cloned in 1997. They were found to be a potential target for treatment of different acute and chronic pain disorder. Recently these receptors were reported to be involved in several pathological conditions. The present study aimed to investigate the potential anticonvulsant activity of five vanilloidal agonists [capsaicin, nonivamide, zingerone, dehydrozingerone and 6-gingerol]. Experimental animal model of pentylenetetrazole [PTZ] induced seizure was used to investigate the potential anticonvulsant activity of capsaicin, nonivamide, zingerone, dehydrozingerone and 6-gingerol. The data obtained showed that, all tested compounds [capsaicin, nonivamide, zingerone, dehydrozingerone and 6-gingerol] possess dose dependant anticonvulsant activity. The five vanilloidal agonists; capsaicin, nonivamide, zingerone, dehydrozingerone and 6-gingerol exhibit anticonvulsant activity and may find clinical application

Ulcerative dermal necrosis [UDN] a freshwater fish disease VI. biochemical investigations

The Nile Tilapia [Oreochromis niloticus] has been infected for four weeks with Saprolegnia. The fish showed white necrotic areas on skin which finally leads to fish death. During the time of infection, the biochemical analysis showed an obvious depletion in the protein content in both muscles and blood serum, while the liver protein content showed a fluctuated behaviour. The liver and muscle glycogen decreased irregulary. The lipids content decreased greatly in the liver while increased in muscles and blood serum. The study showed a reverse relation, allover the time period of infection between glucose level of liver on one side and glucose levels of muscle and serum on the other. The UDN disease has an economic significance since it causes the death of fish stocks in fish culture units and the River Nile