ABSTRACT
Susceptibility to develop IDDM was first found to be associated with class I molecules B8 and B15. Later, DR and DQ allelic genotypes have drawn attention world over to link their role with IDDM pathogenesis to find out the correlation between the frequency of HLA-DRB1, DQA1 and DQBl alleles and the pancreatic beta-cell function in IDDM patients in a trial to use it in clinical evaluation. 22 IDDM patients were studied and 10 healthy individuals of matched age and sex as control group. The patients were further subclassified into 13 patients with residual beta-cell function and 9 patients without residual beta-cell function. Statistical analysis of our results concluded that: DRB1 0304 allele has significant correlation with susceptibility to IDDM [being more common in 25% of patients than in controls 0%]. On the other hand, DRB1 0701 allele was found to be a protective allele against IDDM [segregated more frequently in controls 20% and abscent in patients 0%]. As regard DQA1 and DQBl alleles; the DQA1 0101 alleles has significant correlation with IDDM susceptibility [being more frequent in patients 22.7% and abscent in controls 0%]. Similarly, the DQBl 0201 allele was the most diabetogenic allele more frequent in patients 43.2% than in controls 5%, On the other hand DQA1 0102 and DQA1 0103 alleles are protective alleles against IDDM [segregated more frequently in controls 30% and 15% respectively and abscent in patients 0%]. Also DQBl 0601 allele is protective against IDDM [significantly more in controls 25% than in patients 4.5%]