ABSTRACT
Helicobacter pylori [H.pylori] bacteria colonize human stomach mucosa and may establish acute or chronic gastric inflammation. Cytotoxic-associated gene A [cag A] is associated with higher grades of gastric inflammation and carcinoma. in the present study we determine cag A seropositive strain in dyspeptic patients with H. pylori infection. Six hundred adult dyspeptic patients examined for anti H. Pylori and anti-cag A antibodies by enzyme-linked immunoassay [ELISA] method. All cases resided in east Azarbijan in northwest of Iran and were enrolled in a 5-year period [2003-2008]. A total of 85.5% of dyspeptic patients were positive for H. pylori infection. Anti-cag A antibody was detected in 35.6% of patients with H. pylori infection. Screening of H.pylori infection by ELISA method revealed that the vast majority of [85.5%] dyspeptic patients are seropositive for H. pylori. Determining of photogenic strains of H. pylori by anti-cag A antibody could be diagnostic in severe gastric infections
ABSTRACT
The aim of this study is investigating the association of Helicobacter pylori H. pylori infection and its cytotoxic-associated gene A cagA strain with reflux esophagitis. In a case-control setting May 2005-2006, patients with reflux esophagitis case group were compared with age and gender matched people suffering from symptoms of gastroesophageal reflux disease with normal upper gastrointestinal endoscopic findings control group in Imam Khomeini Hospital, Tabriz, Iran. The rates of H. pylori and its cagA positive infections were separately compared between the 2 groups and the subgroups with different severity of reflux esophagitis. Ninety-two and 93 patients were enrolled in the case and the control groups. The rate of H. pylori infection was insignificantly lower in the case group 81.5% versus 87.10%, p=0.29, odd ratio 0.654, 95% Confidence interval [CI] 0.293 to 1.495. The CagA positive infections were found significantly more frequent in the control group 59.1% versus 40.2%, p=0.01, odd ratio 0.465, 95% CI 0.258 to 0.836. There was no significant difference between the severity subgroups of the disease for H. pylori p=0.30 or cagA positive infection rates p=0.40. The CagA positive strains might have a protective effect against reflux esophagitis