ABSTRACT
The study was a cross-sectional and patient-control study. The study was performed at Al-Azhar university Hospitals from May 2005 to January 2006. The study was performed to document changes in respiratory pump and ventilatory function in idiopathic Parkinson's disease [PD] patients and its relationship with the main clinical presentation and the specific daily living activities [DLA] inthose patients. The study was conducted on 30 patients with PD and 10 healthy control volunteers. Patients were subjected to clinical evaluation by Unified Parkinson Disease Rating Scale [UPDRS] and respiratory pump function evaluation was done for patients and controls. Among patients group, 3 patients had normal pulmonary function [PF], 15 had obstructive PF pattern, 2 had restrictive PF pattern and 17 had upper airway obstruction. A significant disturbance in respiratory neuromuscular drive represent by the tracheal occlusion pressure after 100 m / sec from the start of quit inspiration [PO.l], decrease in respiratory muscle strength evaluated by maximum inspiratory pressure [PImax], marked respiratory muscle fatigue evaluated by [PO.l / PO.lmax]. A significant decrease in partial arterial oxygen pressure [PaO[2]] and increase in PaCO2 was found in patients group when compared to control group. Rigid / hypokinetic group patients 16/30 [53.3%] had significant [p<0.05] respiratory dysfunction rather than tremulous 14/30 [46.7%] group of patients. A significant negative correlation between the duration of disease, severity of illness, total daily living activity [DLA] and the severity of pulmonary dysfunction was found. Among the specific DLA, salivation and severe axial involvement was negatively correlated with maximum voluntary ventilation [MVV], PImax and PaO[2] Patients with Parkinsonis disease have impaired pulmonary function showing both obstructive and restrictive pattern, also abnormalities in mouth occlusion pressure and maximum inspiratory pressure were evident
Subject(s)
Humans , Male , Female , Respiratory Function Tests , SpirometryABSTRACT
The study of routine work in Abbassia and Bab Al Shaaria Chest Dispensaries over the years 1994 1999, reveals the following: The number of subjects examined in both dispensaries was 92768 out of which 833 were diagnosed as tuberculous. The highest percentag of cases was found between age group of 20-40 years. Average percentage of disease in males was 72,9% and. 67.63% while in females was 27.1% and 32.37% in both Abbassia and Bab Al-Shaaria Chest dispensaries respectively. The average percentage of pulmonary TB in Abbassia chest dispensary was 88.89% and extrapulmonary TB percentage was 11.11% while in Bab Al-Shaaria Chest Dispensary the percentage of pulmonary TB was 83.56% and of extrapulmonary TB was 16.44%. The percentage of bronchogenic pulmonary TB was 68% and 65.54% in both Abbassia and Bab Al-Shaaria chest dispensary respectively, while primary pulmonary TB was 9.55% and 5.21% in both Abbassia and Bab Al-Shaaria chest dispensaries respectively. Pleural effusion percentage was 10.67% in Abbassia chest dispensary while ion Bad Al-Shaaria chest dispensary was 12.54% and of miliary TB lesion was 0.67% and 0.27% in both Abbassia and Bab Al-Shaaria chest dispensaries respectively. The number of defaulter cases in Abbassia chest dispensary was 141 cases [31.33%] and in Bab-Al-Shaaria chest dispeary was 39 cases [10.18%]. The relapse rate in Albassia chest dispensary was 3.89% and treatment failure rate was 7.11% while fatality rate was 6.14% but in Bab-Al-Shaaria chest dispensary the relapse rate was 4.06%, treatment failure rate 5.52% and the fatality rate was 2.90%