ABSTRACT
Parkia biglobosa is one of the main medicinal plants used in traditional medicine to treat cardiovascular diseases in Africa. We investigated cardioprotective effects of stem bark hydro-alcoholic extract (HAE) of P. biglobosa in isoproterenol (ISO) induced myocardial infarction (MI). Four groups of five Wistar rats of each were used. Group I, control group, received per os (p.o) saline solution (5ml kg-1 b.w.) as vehicle daily for 15 days and was injected subcutaneously with the vehicle (5ml kg-1 b.w.) at an interval of 24 hours, on day 14 and 15. Group II referred to as infarcted rats, received vehicle p.o and was injected subcutaneously with isoproterenol (125 mg kg-1 b.w.) as in group I. Groups III and IV were pre-treated p.o with HAE (90 and 60 mg kg-1 b.w. respectively) daily for 15 days and was injected subcutaneously Isoproterenol (125 mg kg-1 b.w.). ISO has induced MI, characterized by significant increased (p <0.001) of MDA, biochemical alterations, heart hypertrophy and histological changes in infarcted rats. HAE, prevented significantly (p <0.001) induction of all these anomalies in pre-treated rats. These results suggested cardioprotective effects of P.biglobosa against ISO induced MI.
ABSTRACT
Purpose: Aloe buettneri A. Berger is commonly used in Togolese folk medicine to treat inflammation and gastric ulcer. In this study we investigated the anti-oedema; analgesic; antipyretic and ulcer healing properties of the hydro-alcohol extract of their leaves. Methods: Rat oedema paw were induced by the injection of 0.1 ml of formaldehyde 1; tail flick method is used to study analgesic property; hyperthermia was induced by subcutaneous injection of 15of a brewers' yeast suspension at dose of 10 ml/kg and ulcers were induced by ethanol or HCl/ethanol mixture. Results: The extract showed anti-inflammatory properties at doses between 250-500 mg/kg. It inhibited; in a dose- dependent manner; the oedema induced by 0.1 ml of formaldehyde 1. Scores of 73.70and 83.63were obtned when the doses of extract administered were 100 and 500 mg/kg; respectively. The tail flick analgesic index showed an increase of 36.56when the dose was 500 mg/kg. The extract decreased significantly the hyperthermia induced by the injection of yeast. 1000 mg/kg of the extract inhibited 63.77of the gastric lesion induced by acid-water-ethanol mixture while daily administration of the same dose accele- rated the cicatrisation of gastric ulcer induced by 95ethanol. Conclusion: The results obtained show that the hydro-alcohol extract of Aloe buettneri A. Berger (Lillia- ceae) has anti-inflammatory; anti-ulcer and wound healing properties
Subject(s)
Aloe , Anti-Inflammatory Agents , Anti-Ulcer Agents , Plant Extracts , Stomach UlcerABSTRACT
Ce travail a ete realise dans le but d'evaluer l'activite inhibitrice de falciformation in vitro des extraits de deux plantes couramment utilisees dans le traitement de la drepano- cytose au Togo :Morinda lucida et Newbouldia leavis. Lorsque les hematies sont incubees en presence des extraits vegetaux et du metabisulfite de sodium a 2; on note une diminution concentration- dependante du taux de falciformation par rapport au sang temoin qui a ete incube en presence de NaCl a 0;9a la place des extraits. Morinda a montre un taux d'inhibition de 17;30a la concentration de 1 mg/ml et de 92;31a la concentration de 30 mg/ml sur le sang SS. Sur le sang AS; a la concentration de 1 mg/ml de cet extrait; l'inhibition est de 48;10et 99;34pour 30 mg/ml. Avec N. leavis on a obtenu une inhibition de 15;66a 1 mg/ml et 90;42a 30 mg/ml sur le sang SS. Sur le sangAS cette inhibition est de 64;03pour 1 mg/ml et 99;02pour 30 mg/ml. Ce protocole semble approprie pour travailler aussi bien avec le sang AS qu'avec le sang SS car les effets compares de chacun des extraits sur la falciformation du sang AS et SS ont donne un coefficient de correlation de Pearson qui est de 0;92 pour Newbouldia et de 0;89 pour Morinda. Nos resultats montrent que ces deux plantes ont un effet anti-falciformant evident in vitro et soutiennent l'interet de leur usage en medecine traditionnelle