ABSTRACT
Background: Obesity is associated with significant cardiovascular and thromboembolic risk largely due to increased plateletreactivity. Objectives: To determine the changes in platelet counts and platelet activation using platelet indices (MPV & PDW) inobese and non-obese patients in a tertiary hospital in Uyo, Nigeria.Methodology: This was a cross-sectional descriptive studycomprising of 191 participants recruited consecutively from the out-patients Departments of University of Uyo Teaching Hospitalover a six months period (March-August 2018). Patients were categorised into obese, overweight and normal weight based ontheir Body Mass Index (BMI). Also, 2.5mls of blood was collected from each patient and same was used to determine full bloodcount from where the platelet count and platelet indices (MPV & PDW) were obtained. Results: There was progressive increasein the mean platelet count of the patients (210.59 ± 51.6, 194.26 ± 49.8, 184.95 ± 51.7 for obese, overweight and normal weightrespectively) and this increase was statistically significant (P=0.0208). However, the mean platelet indices (MPV & PDW) wasnot statistically significant (P=0.351 and 0.933 for MPV and PDW respectively). Conclusion: Platelet counts was significantlyelevated in obese patients compared with the overweight and normal weight however, the MPV and PDW was not significantlydifferent in the three groups.
ABSTRACT
Background: The pattern and distribution of haematological malignancies vary depending on age, sex and geographical location. Studies on the association between haematological cancers and ABO blood types have been largely conflicting. Aim: To determine the frequency and distribution of ABO blood groups among a cohort of patients with haematological cancers. Methods: This was a retrospective descriptive cross-sectional study involving the review of records of patients with various haematological cancers, their demographic characteristics and ABO blood group distribution over a 5 year period. Results: The record of 132 patients with haematological malignancies over a 5 year period were reviewed. The mean age of the patients was 47.93 ± 17.9 years. The peak age incidence for the various haematological cancer was the fourth and fifth decades of life. The male to female sex ratio was 2:1. NHL was the commonest haematological cancer among the patients. Majority of the patients were of the O-blood type, the different blood group distribution among the patients was statistically not different from that of the general population. Also, there was no significant association between haematological cancers and ABO blood type of the patients. Conclusion: The distribution, age and sex ratio of haematological malignancies in our study was comparable to those reported by other authors with NHL being the most common haematological cancer in our environment. Majority of the patients were of the O-blood type, comparable to the general population. There was no significant association between haematological cancers and ABO blood type of the patients.