ABSTRACT
This study aimed to identify the substances abused by university students in Upper Egypt, recognizing the risk factors for substance use among Upper Egyptian university students and exploring reasons for initiating the substance abuse. The study comprised 1780 students in three nonmedical faculties belonging to South Valley University [Arts, Education and Commerce]. The diagnosis of "substance use disorders" was based on the definition of DSM-IV. The study tools included a study questionnaire and the socioeconomic class assessment sheet. The study concluded that substance abuse is a serious problem affecting university students in Upper Egypt, especially males. Cannabis as well as sedatives/hypnotics/anxiolytics and opioids are the most frequently abused illicit substances. Smoking is a highly significant risk factor for illicit substance abuse. Mass media and friends constitute the main source for information about the psychoactive substances. The improper family integrity is a major factor leading to illicit substance abuse