ABSTRACT
This work was carried out on 10 healthy volunteers who served as a control group [Gl]. and 50 patients with chronic renal failure. The uremic patients were divided into 5 groups, each consisted of 10 patients. Group 2 [G2] comprised patients with negative HBsAg. Group 3 [G3] comprised patients treated with conservative measures who are chronic healthy carrier for HBsAg. Group 4 [G4] comprised patients treated with conservative measures who suffered from chronic active hepatitis due to HBV infection. Group 5 [G5] comprised dialyzed patients who are chronic healthy carrier for HBsAg. Group 6 [G6] comprised dialyzed patients who suffered from chronic active hepatitis due to HBV infection. The following laboratory investigations were performed to all subjects: complete blood picture, counting of T-lymphocytes, HBsAg, blood urea, serum creatinine, serum bilirubin and serum transaminases. Diagnosis of chronic active hepatitis was confirmed by liver biopsy. Our study showed that chronic renal failure as well as haemodialysis decreased significantly both total lymphocytic count and absolute T-cell count. Total lymphocytic count and absolute T-cell count showed significant negative correlation with blood urea, serum creatinine, duration of dialysis, and the age of patients. HBsAg positive uremic patients showed siginificant reduction in absolute T-cell count, but didn't show significant change in total lymphocytic count, when compared with HBsAg negative uremlc patients. No significant difference could be found in both total lymphocytic and absolute T-cell count between chronic active hepatitis uremic patients and chronic healthy carrier uremic patients. Finally, no significant correlation was detected between the biochemical parameters of liver function [total serum bilirubin, SGOT and SGPT] and both total lymphocytic count and absolute T-cell count