ABSTRACT
Macrophage colony stimulating factor [M-CSF] is a hematopoietic growth factor produced by monocytes, granulocytes, endothelial cells, and fibroblasts. M-CSF augments the ability of mature macrophages and monocytes to kill microorganisms by enhancing their production of superoxides and cytokines. This study was designed to determine whether perinatal complications induce the production of M-CSF or sepsis, so we have compared M-CSF levels in the cord blood between group I normal neonates, group lla neonates with perinatal complications e.g., premature rupture of membranes [PROM], C.S., prematurity, post data, diabetic and hypertensive mothers and group lib neonates with complications after getting infected. As regard the results of MCSF among the studied groups it was found that M-CSF level was higher in group ha and group IIb than group I [2827.3 +/- 1391.3 pg/mi], [3840.3 +/- 806.9 pg/mI], [657.5 +/- 458,3 pg/mI] respectively, and this differences were highly statistically significant. it was found also non significant difference between M-CSF levels among the diverse perinatal complications what so ever, The level of M-CSF in group lib [who developed infection] was higher after developing sepsis [3993.9 +/- 983. 2pg/ml] than before [3840.3 +/- 806.9 pg/mI] but without significant statistical difference. M-CSF levels in the cord blood from neonates with perinatal complications were significantly higher than those in the cord blood sampled from normal neonates and determination of its level in the neonates with perinatal complication will not be of vulnerable clinical significance as an early marker of sepsis