ABSTRACT
Background: Measuring of maternal serum pregnancy-associated plasma protein-A [PAPP-A] in first trimester can be a way for early detection of adverse prenatal outcome due to faulty placenta
Objective: The aim was to Determination of association between placental thickness in second trimester with low level of PAPP-A in first trimester
Materials and Methods: In this cohort study, serum PAPP-A of 187 pregnant women was measured in the first trimester of pregnancy. Patients who had PAPP-A /= 0.8 defined as unexposed group. The criteria of placental thickness in ultrasound study was thickness of 4 cm or more than 50% of placental length
Results: Of 187 patients, 87 patients had PAPP-A >0.8 and 93 patients had PAPP-A
Conclusion: Our study showed that serum level of PAPP-A generally was low [4 cm or >50% of placental length]. The first trimester of pregnancy measurement of PAPP-A will be more predictable for healthy placenta