ABSTRACT
Sirakamba vatham is a clinical entity described by Sage Yugi in his treatise Yugi Vaithiya Chinthamani- 800, as one among the 80 types of Vatha diseases described in Siddha system of medicine. The study was aimed at in depth analysis of the clinical features mentioned under Sirakamba vatham of Siddha literature and to evolve standard Siddha diagnostic methods for management for Sirakamba vatham. This study was an observational, single center study with the sample size of 26, divided into Group I (control group) having normal individuals and group II (cases with Sirakkamba vatham). At the end of the study, it was concluded, that the symptoms of Sirakkamba vatham closely resembled the symptoms of Cerebro Vascular Accident especially of posterior circulation stroke.
ABSTRACT
The Siddha system of medicine is widely practiced in South India and consists of an enormous classical literature that emphasize on pathological basis of disease. Contrary to conventional pathological basis of diseases, the Siddha pathology is solely based on the humoral makeup of individuals and rests on the conceptual framework formed by 96 Thathuvams (philosophies). These concepts connect the physical and inert energies of human body facilitating its existence at subtle and gross levels. Sirakkambavatham is one among the 80 Vatha diseases mentioned in the Siddha literature Yugivaithiyasinthaamani. The present literature survey has been conducted to provide an updated integrative framework of information about the pathological concepts of Sirakkambavatham from Siddha literature and its parallel analysis with Cerebrovascular accidents (Stroke).Validating the traditional text in the limelight of modern literature unveils the traditional wisdom of ancient saints of South India and provides a better approach for disease diagnosis, prevention and its management.
ABSTRACT
Siddha system is an ancient system of medicine which is popularly practised around south India particularly in Tamilnadu. Siddhars were considered as the pioneer of Siddha system, this system of medicine mainly encompasses for a healthy life for human beings. Among the broad spectrum of treatment aspects in Siddha system Siddhars classify the forms of internal medicines into 32 types which are all unique by its preparations. Choornam is one of the forms of internal medicine which can be used as single as well as poly herbal formulations. In this case report a poly-herbal formulation in Siddha system was used to treat tension type of headache (TTH). A 30 years old male patient visited out-patient department of Ayothidoss Pandither Hospital in National Institute of Siddha, Chennai. Patient reported with the complaints of episodic and chronic headache which is band like around the head, the intensity becomes mild to moderate, pain increased during working hours for past 2 years. Patient advised to follow the internal medicine Chundai vatral choornam it relives the TTH immediately when he got those symptoms.
ABSTRACT
Background: Molecular docking has tremendous applications in the field of Siddha medicine especially herbal formulations were the interactions of the lead molecules of the formulation with that of receptors can be elucidated at the molecular level and furthermore to reach an assumption of its fundamental biochemical processes to which the formulation is targeting. Kuppaimeni Choornam (KC) is a simple herbal formulation used in Siddha medicine for urticaria and other skin allergies. As far as skin allergy is concerned Amino acids such as Asparagine (ASN), Tryptophan (Trp), Aspartate (Asp), Tyrosine (Tyr), Serine (Ser), Isoleucine (Ile), Lysine (Lys), Threonine (Thr), Phenylalanine (Phe) are the main core residues involved in mediating Human histamine receptor (3RZE). Binding of lead compounds with this core residue may inhibit the enzyme activity. Aim & Objectives: Molecular docking studies of Siddha herbal formulation KC and to screen the lead component interaction on the Human Histamine Receptor (3RZE). Methodology: Docking calculations were carried out using Auto Dock 4. Gasteiger partial charges were added to the ligand atoms. Docking simulations were performed using the Lamarckian genetic algorithm (LGA) and the Solis & Wets local search method. Initial position, orientation, and torsions of the ligand molecules were set randomly. All rotatable torsions were released during docking. Results and Conclusion: The compounds present in KC like beta-sitosterol, apigenin, luteolin, cuminaldehyde, kaempferol, and triacetonamine showed maximum interactions with 3RZE when compared to that of the standard cetirizine. Hence, these compounds of test drug possess promising Human histamine 1 receptor (3RZE) inhibition activity. For prospective pharmacological validation of Kuppaimeni Choornam, the docking studies were an important step for its scientific justification.
ABSTRACT
Karpoora Cinthamani Mathirai (KCM) is a traditional Siddha medicinal preparation using to treat Arthritis associated with fever narrated in the text Anubhoga Vaithiya Navaneetham. This formulation has the detoxified ingredients such as Hydrargyrum subchloride and Croton tiglium seeds. The aim was to establish a fingerprint to ensure the quality and safety of KCM. Physicochemical characterization of KCM was carried out using qualitative biochemical analysis and modern techniques such as Fourier transform infra-red spectroscopy, inductively coupled plasma analysis and scanning electron microscopy. Physical evaluation revealed that KCM is a light green colour pill, neutral nature and having solubility in water and HCl with stabilized particle size distribution of 3μ. A clearly identifiable fraction of KCM particles were below 50 nm. The presence of nano sized particles and functional groups carboxylic acids and nitrocompounds in KCM might impart the therapeutic property. Trace elemental analysis of KCM revealed that heavy metals like arsenic, cadmium, mercury and lead were below the deduction limit. Further, elemental analysis of KCM revealed the presence of minerals like calcium, iron, potassium, sodium, and phosphorus under acceptable limits at the prescribed dose of KCM.
ABSTRACT
Handa et al., 1986 noted that in India, more than 87 plants are used in 33 patented and proprietary multi-ingredient plant formulations for liver protection. Siddha Materia Medica illustrates a safer, cheap and potential hepatoprotective polyherbal decoction ‘Pidangunaari kudineer’ comprised of three herbal ingredients such as leaves of Premna tomentosa, pericarp of ripe fruits of Terminalia chebula, rhizomes of Curcuma longa. This formulation is very effective against hepatitis in the clinical practice. The goal of this systematic review of the literature was to summarize the literature on the safety and hepatoprotective activity of above herbs. A manual search of bibliographies of papers identified through an Internet search using multiple search engines. Textbooks on herbal medicine and their bibliographies were also searched. Result and Conclusion: A large number of in vitro, in vivo, human clinical studies on those herbs were identified. These included studies on the antioxidant, anti-inflammatory, antihepatoxicity induced by acetaminophen and antituberculosis drugs, anticarcinogenicity, antimicrobial properties and also phytocompounds were identified to justify the safety and hepatoprotective efficacy. Ethnic background of these herbs results liver protection make Pidangunaari Kudineer for further screening for hepatoprotection.