ABSTRACT
This work aimed to study the pulse pressure [PP] as a predictor of increased risk of cardiovascular diseases [CVD] in middle-aged hypertensive patients. This study included 100 middle-aged patients with newly diagnosed essential hypertension and had not received any anti-hypertensive medications previously. PP was calculated for all patients who were classified into 2 groups; hypertensives with PP = 50 mmHg and those with PP>50 mmHg. All the included patients have been studied by electrocardiography and echocardiography. The number and percentage of patients with left ventricular hypertrophy [LVH] were significantly higher in the group of hypertensive patients with PP>50 mmHg than those with PP = 50 mmHg. Also, the left ventricular mass [LVM] and the left ventricular mass index [LVMI] were significantly higher in hypertensive patients with PP>50 mmHg than those with pp = 50 mmHg. In addition, this study showed that PP was significantly positively correlated to LVMI after adjusting for systolic blood pressure [SBP], age, sex and body mass index [BMI]. A pulse pressure [PP] >50 mmHg in middle-aged hypertensive patients is a predictor of LVH and increased risk of CVD independent of SBP so, the width of PP must be considered in the risk assessment of hypertensive patients and antihypertensive medications reducing the PP should be evaluated in the future