Lipid profile and foetal outcome in obese pregnant females

To compare lipid profile and foetal outcome in obese pregnant females to non obese women delivered in Alexandria. The study is a case control study of women registered at El-Shatby Maternity University Hospital at the time of delivery in the period between June 2009 and June 2010. The cases were 50 pregnant obese women [BMI>30Kg/ m2] aged 20-30 years. The controls were 50 normal pre-pregnancy weight women with [BMI 18.5-24.9 Kg/ m2] matched with cases as regards age and gestational age. Data were gathered from women who delivered in addition to their caring obstetricians involved as well as reviewing the medical records. Laboratory investigations included assessment of lipid profile [serum cholesterol, and serum triglycerides] at the time of delivery. Also, leptin hormone was measured in serum of patients using DRG Leptin [Sandwich] ELISA [EIA-2395] USA. Caesarean section rate was significantly higher among obese women [82% versus 30%; P<0.001]. The mean serum leptin concentration was significantly higher in obese women [BMI>30 kg/m2] than normal weight controls [p=0.013]. Neonates born to obese had a statistically significant increased birth weight than infants of normal weight participants [P=0.0001]. Additionally, neonates born to obese women had an increased risk of admission to Neonatal Intensive Care Unit OR [4.1], 95% [CI] 1.2-2.4, p<0.001. Obesity is associated with increased adverse maternal and perinatal complications

Study of some haemostatic and inflammatory parameters in preeclamptic and normotensive pregnant females

Preeclampsia is an idiopathic multisystem disorder specific to human pregnancy characterized by gestational hypertension and proteinuria. It complicates many pregnancies and is the third common cause of maternal and neonatal mortality and morbidity. The aim of the present work was to elucidate the relationship between serum maternal levels of C-reactive protein [CRP] as an inflammatory marker and coagulation and fibrinolysis as haemostatic markers in preeclamptic and normotensive pregnant females compared to non-pregnant females. Sixty females were enrolled in the study divided into ten non pregnant healthy females as the control group [Group I], twenty five normotensive pregnant females [Group II], twenty five preeclamptic pregnant females [Group III]. The pregnant females all were primigravidae, in the third trimester of pregnancy. For all these females C-reactive protein was measured as an inflammatory marker. Haemostatic parameters included platelet count, prothrombin time, activated partial thromboplastin time and thrombin time as coagulation parameters while fibrinolytic parameter included euglobulin clot lysis time. The results showed a significant negative correlation between CRP and platelet count in preeclamptic group. It also showed a higher positive correlation between CRP and Euglobulin Clot Lysis Time [fibrinolysis parameter] in preeclampsia than in the normotensive and control groups