ABSTRACT
Schistosoma mansoni infection continues to be one of the most serious parasitosis worldwide due to its debilitating effects, mainly hepatic fibrosis. The present study explored the antifibrotic effect of resveratrol [RSV], either alone or in combination with praziquantel, on the murine model of intestinal schistosomiasis. We performed two parallel experiments exploring the preventive and the curative effect of RSV on inflammation and fibrosis. Parasitological measurements [adult worm burden, oogram], biochemical [AST, ALT, hydroxyproline], histopathological and histobiochemical studies were performed. The results revealed that RSV has significant curative and preventive outcome on hepatic fibrosis and this effect is augmented when coupled with praziquantel. Other parasitological and biochemical parameters were enhanced as well
ABSTRACT
Hydatid disease is endemic and represents a major health problem in Yemen. The aim of this study is to determine the magnitude of the problem of hydatidosis in patients attending Public and Private Hospitals at Sana'a city, Yemen. 66 patients with hydatid disease were identified during the period from August 2006 to February 2007. Complete medical history for all CE patients were collected and analyzed. Among the 66 CE patients, 67% were females and 33% males. Liver was the most common involved organ. Single cyst was more frequently detected than multiple cysts and approximately 94% of the cysts were >/= 5 cm. Moreover, Public hospitals were the main source of patients with CE disease. Hydatidosis is still an endemic disease and an important health problem in Yemen which needs to be studied further. Therefore, accurate information on the distribution of the disease is the first step for the control and prevention of the disease. Moreover, it is crucial to investigate the role of different intermediate hosts and genotypes of E. granulosus in humans and animals