ABSTRACT
Non-drug therapy of traditional Chinese medicine (TCM) mainly includes exercise therapy, such as Baduanjin and Taichi. Some TCM techniques adjunct toanti-hyperhension drugs show effectiveness with safety, such as moxibustion, acupuncture, acupoint application, auricular point application, massage, cupping, scraping, herbal tea, emotional therapy, and music therapy. In future, long-term follow-up of trials and standardization of research are needed. In the other way, in-depth research on patients with grade 3 hypertension and secondary hypertension is still needed.
ABSTRACT
Iron homeostasis plays an important role for the maintenance of human health. It is known that iron metabolism is tightly regulated by several key genes, including divalent metal transport-1(), transferrin receptor 1(), transferrin receptor 2(), ferroportin(), hepcidin(), hemojuvelin() and . Recently, it is reported that DNA methylation, histone acetylation, and microRNA (miRNA) epigenetically regulated iron homeostasis. Among these epigenetic regulators, DNA hypermethylation of the promoter region of , and bone morphogenetic protein 6 () genes result in inhibitory effect on the expression of these iron-related gene. In addition, histone deacetylase (HADC) suppresses gene expression. On the contrary, HADC inhibitor upregulates gene expression. Additional reports showed that miRNA can also modulate iron absorption, transport, storage and utilization via downregulation of and other genes. It is noteworthy that some key epigenetic regulatory enzymes, such as DNA demethylase TET2 and histone lysine demethylase JmjC KDMs, require iron for the enzymatic activities. In this review, we summarize the recent progress of DNA methylation, histone acetylation and miRNA in regulating iron metabolism and also discuss the future research directions.
Subject(s)
Humans , Epigenesis, Genetic , Gene Expression Regulation , Genetics , Homeostasis , Iron , Metabolism , Receptors, TransferrinABSTRACT
A 33-year-old male receiving dorsal penile nerve block (DPNB) for circumcision exhibited a postoperative ischemic change over the glans penis. The event occurred nearly 24 hours after the procedure. The patient was treated with intravenous pentoxifyllin and hyperbaric oxygenation. Total reverse of the ischemia was observed. The complications associated with circumcision and DPNB were reviewed and discussed.