ABSTRACT
Pre-labour rupture of the membrane is a common clinical problem, and the assessment of the woman with possible membrane rupture is management issue faced in every day practice. When premature rupture of membrane [PROM] occurs, the fetus loses the relative isolation and protection afforded within the amniotic cavity. To evaluate the reliability of vaginal washing fluid Beta-human chorionic gonadotropin for the detection of premature rupture of membrane and to determine a cut-off value. A prospective case-study includes 79 pregnant women subdividing into three groups [group A: 20 pregnant women with confirmed premature rupture of membranes, group B: 19 pregnant women with suspected premature rupture of membranes, group C: apparently healthy pregnant women without any complaint] for which speculum examination for amniotic pooling, nitrazine paper test, measurement of vaginal washing fluid Beta-human chorionic gonadotropin were performed. There was significant differences in mean vaginal washing fluid fl-HCG concentration among the three groups [p= 0.000], being higher in group A than the other two groups and the time interval between sampling and delivery was significantly shorter among patient in group A than group B and C. Vaginal fluid 3-HCG determination is reliable, simple and rapid test for the detection of PROM