ABSTRACT
Recently, epidermal mucus of fish has been identified as a rich biological source of various bioactive substances,particularly antibacterial peptides. This study was conducted to identify the potential of epidermal mucosa of Clariasbatrachus as a source of antibacterial material. Mucosal samples were collected from C. batrachus epidermis and extractedusing an aqueous extraction method. Antibacterial activity of the crude epidermal mucus extract was determined byusing spectrophotometric method. As a result there was antibacterial activity by the mucus extract against Escherichiacoli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). The results of this study supports the role of mucus asa part of body immune system with antibacterial peptide as a component of innate body immune system. Hence, thesefindings can be used as one of the first steps towards the development of new class antibiotics.