ABSTRACT
The aim was to evaluate pathologic diagnosis, treatment and prognosis of 125 patients with nontransitional cell carcinoma of the urinary bladder. A total of 3590 patients with bladder tumors operated in our clinic between September 1998 and May 2013 were retrospectively evaluated. A total of 125 patients [107 men and 18 women] with nontransitional cell bladder cancer, confirmed by histopathology, were included in this study. The patients' characteristics, including age, gender, smoking history, tumor size, and localization, histological types, pathological tumor stages, treatment modalities, and survival rates were all recorded. Of these tumors, 47 [37.6%] were adenocarcinoma [AC], 42 [33.6%] were squamous cell carcinoma [SCC], 23 [18.4%] were undifferentiated carcinoma [UC], 13 [10.4%] were other types of bladder carcinoma. Sixty-three [50.4%] patients had undergone radical cystectomy and pelvic lymphadenectomy +/- adjuvant treatment [chemotherapy [CT]/radiotherapy] and 52 [41.6%] patients received radiotherapy +/- CT. The median survival time of patients with AC and SCC were significantly higher than patients with UC [AC vs UC, P = 0.001; SCC vs UC, P = 0.000; AC vs. SCC, P = 0.219]. Median survival time was significantly higher in radical cystectomy +/- adjuvant treatment group [P < 0.05] in all histological types. Prognosis of urinary bladder tumors was directly related to histological type and stage of the tumor. CT or radiotherapy has limited response rates. Early radical cystectomy should be performed to improve prognosis
ABSTRACT
BACKGROUND: Because there may be interdepartmental differences in macroscopic sampling of cholecystectomy specimens, we aimed to investigate differences between the longitudinal sampling technique and our classical sampling technique in cholecystectomy specimens in which there was no obvious malignancy. METHODS: Six hundred eight cholecystectomy specimens that were collected between 2011 and 2012 were included in this study. The first group included 273 specimens for which one sample was taken from each of the fundus, body, and neck regions (our classical technique). The second group included 335 specimens for which samples taken from the neck region and lengthwise from the fundus toward the neck were placed together in one cassette (longitudinal sampling). The Pearson chi-square, Fisher exact, and ANOVA tests were used and differences were considered significant at p<.05. RESULTS: In the statistical analysis, although gallbladders in the first group were bigger, the average length of the samples taken in the second group was greater. Inflammatory cells, pyloric metaplasia, intestinal metaplasia, low grade dysplasia, and invasive carcinoma were seen more often in the second group. CONCLUSIONS: In our study, the use of a longitudinal sampling technique enabled us to examine a longer mucosa and to detect more mucosal lesions than did our classical technique. Thus, longitudinal sampling can be an effective technique in detecting preinvasive lesions.