ABSTRACT
Background: Previous studies have shown that hepatic fibrosis indices and rates can be used to predict cardiovascular mortality and morbidity. Our aim with this study was to investigate the effect of aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio and fibrosis?4 (FIB?4) index calculated with ALT, AST, and platelet biomarkers, which are simple, fast, and relatively inexpensive and were used in previous studies to predict cardiovascular disease prognosis, on the prediction of postoperative morbidity and early mortality after mitral valve replacement (MVR) surgery. Methods: By scanning the hospital electronic health record system, 116 patients who underwent isolated MVR or MVR + tricuspid valve intervention were identified from 178 patients who underwent MVR with the standard sternotomy procedure between 2011 and 2021. The study was completed with 81 of these patients. Patients were divided into AST/ALT <2 (Group 1) and >2 (Group 2). In addition, the same patients were divided into FIB?4 index <3.25 (Group 3) and >3.25 (Group 4), and a total of four groups were formed. Results: The mean age of Group 2 was significantly higher than Group 1 (P = 0.049). In addition, the mean age of Group 4 was significantly higher than Group 3 (P = 0.003). Postoperative complications did not differ between Groups 1 and 2 (P > 0.05). While noninvasive mechanincal ventilation (NIMV) requirements did not differ between Groups 3 and 4 (P > 0.05), MV duration and intensive care unit stay were significantly longer in Group 4 (P < 0.05). Conclusion: The AST/ALT ratio, which has been shown to be a predictor of cardiovascular mortality in various studies, was not useful in predicting mortality and morbidity in our study. However, a high FIB?4 index, another hepatic fibrosis index, was found to be associated with increased perioperative bleeding, duration of mechanical ventilation, and cardiac intensive care unit stay, which are important criteria in the prediction of morbidity in cardiovascular surgery.
ABSTRACT
We have compared the effect of low dose rocuronium on intraocular pressure [IOP] in larygeal mask airway usage during induction of anesthesia using propofol and fentanyl, in a randomized, double-blind study. We studied 30 patients randomly allocated to one of two groups. Anesthesia was induced with fentanyl 1 mg kg[-1] and propofol 2 mg kg[-1] until loss of eyelash reflex. This was followed by rocuronium 0,3 mg kg[-1] [group R, n=15] and normal saline [group S, n=15]. IOP was measured with Schiotz tonometry device preoperatively [IOP[pre]] and after propofol infection [IOP[0]] and immediately after LMA insertion [IOP[1]], 1. [IOP[2]], 2. [IOP[3]], 3. [IOP[4]], 4. [IOP[5]] and 15. [IOP[15]] minutes after laryngeal mask airway [LMA] insertion and after extubation [IOP[ext]]. The collected data were heart rate [HR], oxygen saturation [SpO[2]], end-tidal carbon-dioxide pressure [ETCO[2]] and mean arterial pressure [MAP]. After LMA insertion significant decrease was found in IOP in both groups. No significant difference was found between groups. Although there have been reports that LMA insertion minimally increases IOP, in our study, by using low dose rocuronium and LMA there was a decrease in IOP
ABSTRACT
Postoperative seizures [expected after neurosurgery] are rare events. When they do occur, they are usually attributable to an identifiable drug reaction, a metabolic or neurological event. We report a case of postoperative seizure in postanesthesia care unit. A 19-yr-old female, 48 kg, was admitted to a hospital for left middle-ear surgery. Her medical history, physical examination and laboratory evaluation were normal. Anesthesia was induced with fentanyl 1 micro g/kg, thiopental 5 mg/kg and rocuronium 0.5 mg/kg to produce neuromuscular blockade. Anesthesia was initially maintained with oxygen, nitrous oxide and sevoflurane. Mastoid surgery was completed in 195 minutes after induction. The patient was extubated, but approximately 10 minutes after arrival in recovery she started to generalized tonic clonic convulsion. Oxygen was administered by face mask and thiopental 100 mg was administered intravenously. Blood sugar, electrolytes and body temperature were normal. After ten minutes convulsion episode was repeated. Because of the continuing seizure activity in a patient at risk of pulmonary aspiration and security of air way, her trachea was intubated by using thiopental and succinylcholine and ventilation controlled artificially. The seizures were controlled with midazolam and phenytoin. Computerized tomography [CT] showed left temporal cortical suspected hipodensity [Fig. 1] and the patient was transferred to ICU