To correlate the serum levels of adiponectin with fasting and random blood sugars in diabetes mellitus and healthy individuals

To correlate the serum levels of adiponectin with fasting and random blood sugars in diabetic and healthy individuals. Comparative cross sectional study. The study was carried out at the Department of physiology B.M.S.l. J.PM.C. in collaboration with Abassi Shaheed Hospital Karachi from August 2007 to July 2009. This study included total 100 subjects, 50 subjects with known case of Diabetes Mellitus and 50 normal healthy age and gender matched controls. A significant negative correlation [r = 0.65 and r = 0.80] [P<0.01] was found between fasting and random blood sugars and serum adiponectin in Diabetics. This suggests that higher levels of serum adiponectin may be protective against the development of Diabetes Mellitus

Vitamin E ameliorates renal damage in streptozotocin induced diabetes in albino rats

This study was designed to find out the role of Vitamin E on serum glucose and Creatinine concentrations of male albino rats made diabetic by streptozotocin. Prospective study. This study was conducted at the Department of Physiology; Basic Medical Sciences Institutes [BMSI], Jinnah post Graduate Medical Center [JPMC], Karachi from Feb. 2010 to March 2010. In a 4 weeks study, 45 male albino rats were divided into 3 groups containing 15 animals each. Group A was treated as control, Group B and Group C received 45 mg/kg STZ once at the start of the experiment whereas Group C additionally received 600 mg/kg Vitamin E Intramuscularly 3 times weekly. Serum glucose and Creatinine concentrations were measured at the beginning of the experiment and once weekly. Serum glucose and Creatinine levels were significantly elevated in Group B as compared to control. In Group C, blood glucose was elevated but the levels of serum Creatinine were significantly reduced, when compared to group B. our findings conclude that Vitamin E supplementation may have protective effects against deterioration of renal function brought about by free radical toxicity in diabetes mellitus

[Serum lipids in normotensive and preeclamptic pregnancies]

To determine maternal serum lipid levels in patients with preeclampsia compared with normoten-sive pregnant women matched for height, weight, age and gestational age. It was a case- control study conducted in the Department of Physiology B.M.S.I. J.P.M.C. Karachi, in collaboration with department of Gynaecology and Obstetrics from November 2005 to July 2006. Fifty Preeclamptics and fifty normotensive women were prospectively recruited for this study matched for height, weight, age and gestational age. Only nulliparous subjects with singleton pregnancies were included in this study. The mean values of serum triglycerides and VLDL - cholesterol were highly significant [P<0.001] in preeclamptics as compared to the control group, and a significant lower [P<0.05] values of serum HDL- cholesterol in preeclamptics as compared to the control group and the non - significant difference between the values of total cholesterol and LDL-cholesterol between the two groups were found. The findings suggested that women with preeclampsia had altered lipid profile, so it may be useful to measure first trimester serum lipid levels which may have potential in predicting pregnancies destined to become complicated by preeclampsia. Early identification would be of considerable clinical value for appropriate management of these high risk patients