ABSTRACT
Trypanosoma cruzi infection and nonsteroidal anti-inflammatory drugs inhibit colorectal carcinogenesis by mechanisms not completely known and metallothionein proteins (MTs) may be involved in this process. Sixty-six male Wistar rats weighing 90 to 120 g were randomly divided into seven groups (GI to GVII). GI, GII and GIII animals were subcutaneously infected with 200,000 trypomastigote forms of the Y strain of T. cruzi. After 8 weeks, GI, GII, GIV, and GVI were injected with one weekly subcutaneous dose of 12 mg/kg dimethylhydrazine for 4 weeks. In sequence, GI, GIV and GV were treated with nimesulide (10 mg/kg per dose, five times per week for 8 weeks). Groups I, III, IV, and VI had 12 animals, and each of the other groups had 6 animals. All the animals were euthanized 8 weeks after the last dimethylhydrazine injection. The colons were fixed and processed for MT immunohistochemistry. The index of MT-overexpressing colonic crypts (MTEC) was estimated as the percentage of MT-stained crypts in relation to the total number of crypts scored. Five hundred crypts per animal were scored. Data were analyzed by the Kruskal-Wallis test followed by the Dunn test. There was an increase in MTEC index in the groups either infected with T. cruzi or treated with nimesulide or both infected and treated when compared to control (401, 809, and 1011 percent, respectively). We suggest that the increased formation of MTEC may be related to the protection against carcinogenesis provided both by T. cruzi infection and nimesulide.
Subject(s)
Animals , Male , Rats , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Chagas Disease/congenital , Colorectal Neoplasms/metabolism , Metallothionein/metabolism , Sulfonamides/pharmacology , Carcinogens , Colorectal Neoplasms/complications , Colorectal Neoplasms/prevention & control , Dimethylhydrazines , Disease Models, Animal , Immunohistochemistry , Metallothionein/drug effects , Rats, WistarABSTRACT
La variación diaria en la aparición de Accidente Cerebro Vascular (ACV) fue examinada en 255 pacientes. Estos incluyeron 173 isquemias y 82 hemorragias intraparenquimatosas (HI). Los pacientes fueron ordenados en despiertos y dormidos, y distribuidos en 4 períodos de 6 horas cada uno. La frecuencia de aparición de ACV isquémico fue significativa (p<0,001) para el período de 08 a 14 horas (46,6%); para las HI también fue significativa (p<0,001) para el mismo período (46,3%). Se analizaron otras variables: edad, sexo y tipo de lesión relacionándolas con el estado del paciente (despierto-dormido) y con el momento (día-noche) en que ocurrió el ACV. El análisis de los pacientes con ACV isquémico y hemorrágico con manifestación al despertar mostró una frecuencia significativa (p<0,001) para las isquemias (81,3%) que para las HI (18,7%)
Subject(s)
Humans , Male , Female , Middle Aged , Cerebral Hemorrhage/epidemiology , Brain Ischemia/epidemiology , Cerebrovascular Disorders/epidemiology , Circadian Rhythm/physiology , Wakefulness , Cerebral Hemorrhage/physiopathology , Brain Ischemia/physiopathology , Cerebrovascular Disorders/physiopathology , Sex Factors , Cross-Sectional Studies , Prospective Studies , Multicenter Studies as Topic , Age Factors , Multivariate Analysis , Blood Pressure/physiology , SleepABSTRACT
Leiomiossarcoma do cólon é uma doença muito rara. É relatado o caso de um doente masculino, 43 anos, com este diagnóstico, que apresentava dor abdominal, diarréia e massa abdominal palpável. Foi feita também uma revisäo da literatura
Subject(s)
Male , Adult , Leiomyosarcoma/etiology , Colonic Neoplasms , VenezuelaABSTRACT
Se presenta por vez primera en nuestro medio la aplicación de una Escala de Monitoreo clinico en el seguimiento del paciente neurológico. Se controlaron 50 pacientes con un protocolo único lo que permitió fijar pautas. Se evaluó la Cuadrícula destacando aspectos positivos y dificuldades halladas en la puesta en práctica. Se mostraron y discutieron casos individuales de sumo interés. Por último se deja abierto el camino para interesantes perspectivas futuras (