ABSTRACT
Objectives: Our aim was to evaluate the impact of neutrophil to lymphocyte ratio [NLR] in patients with metastatic testicular cancer [tCa]
Design: Retrospective view of prospective recorded data
Setting: Clinical study was conducted at multicentre between May 2010 and September 2016
Subjects: Patients with tCa who underwent radical orchiectomy were enrolled. Similar surgical methods, laboratory analyses, and radiologic examinations were performed and all patients were divided into 2 groups. Group 1 [n = 108] consisted of patients with non-metastatic testicular cancer; Group 2 [n = 38] consisted of patients with metastatic [solid organ-lymph node metastasis] tCa
Intervention: Radical orchiectomy, blood sample
Main outcome measures: Demographic, preoperative, and postoperative data were noted. Postoperative complications were interpreted according to modified Clavien classifications. Statistical significant p was p
Results: Mean follow-up was 36.4 [4 - 72] months. Mean age was 39 years [19 - 71 years]. There were significant differences between groups in preoperative NLR, tCa markers and diameter of tumour [p = 0.03, p <0.001, p = 0.01, respectively]. Besides, invasion to lymphovascular, rete testis, cord, epididymis, and surgical margin positivity, postoperative tCa markers were significantly higher in group 2 than group 1. Area under ROC curve was 0.69, [p <0.001] and cut-off value for NLR was 3.11 in terms of any metastasis. There was no serious complication after operation. Five patients experienced wound infections [Clavien 1]
Conclusions: Preoperative NLR could help us to predict lymph node and solid organ metastasis in patients with tCa. If the NLR is over 3.1, clinicians should be aware of metastasis