Prevention of rhinitis medicamentosa

We report the histological and histochemical changes of the respiratory mucosa of the guinea pigs nasal cavity after nasal instillation by decongestant 0.05% Naphazoline Hydrochloride drops under conditions of feeding of normal diet and by adding additional quantities of vitamin C and B[2]. The results revealed that the nasal instillation by 0.05% Naphazoline can provoke a series of histological and histochemical changes in the respiratory mucosa of guinea pigs nasal cavities, but all these changes can be reduced significantly by increasing the supply of vitamin C and B[2] in the feeding of the animals