ABSTRACT
Objective: To assess the efficacy of tranexamic acid in reduction of blood loss and pervention of postpartum hemorrhage after vaginal delivary
Methods: This is a multicentric prospective randomized double blind placebo controlled trial. 200 pregnant women were randomized to receive either 60 mg/kg of tranexamic acid [TA] [n=100] or placebo [n=100] intravenously in the second stage of labour. Postpartum blood loss was collected and measured accurately from placental delivery to 2 hours postpartum and adverse effects of were observed
Results: The mean estimated postpartum blood loss was significantly lower in women treated with tranexamic acid compared to women in the placebo group [442.50 +/- 128.55 versus 555.75 +/- 191.88, respectively; p < 0.001], and the proportion of women in the tranexamic acid group who had an estimated blood loss >/= 500 mL was significantly lower than in the placebo group[3 [3 %] versus 9 [9%],relative risk [RR]=0.30; 97% confidence interval [CI] 0.11 to 0.78;P<0.05]. Maternal and neonatal outcomes did not differ significantly between both groups
Conclusion: The addition of tranexamic acid to the active management of third stage of labor after normal vaginal delivery is effective as a prophylaxis against post-partum hemorrhage. It can significantly reduce blood loss during and after delivery