Formulation and in-vivo study of ketoprofen tablets prepared using chitos an interpol ymer complexes

The application of interpolymer complexes [IPCs] for oral controlled drug delivery systems was tested between chitosan and various anionic polymers viz sodium alginate, sodium carboxymethylcellulose and pectin. The prepared IPCs were investigated using Fourier transform infra-red spectroscopy and differential scanning calorimetry, Ketoprofen tablets were prepared using the polymers alone, physical mixtures of chitosan with sodium alginate, sodium carboxymethylcellulose or pectin in different ratios; 1:3, 1:1 and 3:1, and the corresponding IPCs. In-vitro release studies were carried out in two dissolution media; 0.1 N HCl ofpH 1.2 and phosphate buffer ofpH 7. 4. It was found that, chitosan - sod. carboxymethylcellulose 1PC tablets showed more controlled drug release compared to that containing chitosan - sodium alginate and chitosan -pectin IPCs. The dissolution rate from tablets prepared using physical mixtures of polymers were found to be dependant on the interaction between chitosan and each of the anionic polymers in the physical mixtures, their ratios and pH of the dissolution medium. Tablets prepared using chitosan - sod. carboxymethylcellulose physical mixture 1:1 and chitosan - sod. carboxymethylcellulose IPC were selected for the in-vivo study using albino rabbits. The results showed a lower peak plasma concentration and marked controlled release effect of drug in tablets containing the physical mixture compared to that of the IPC and the control tablets

Formulation and stability study of naproxen ophthalmic preparations

Naproxen was formulated in different ophthalmic preparations as drops, gels and ocuserts using cellulose derivatives such as methylcellulose, sodium carboxymethylcel-lulose and hydroxypropyl methylcellulose. All the prepared formulae [drops, gels and ocuserts] containing the drug were subjected to the study of the release characteristics. Also, the stability of naproxen ophthalmic preparations at different conditions of storage were investigated. The obtained results revealed that, the percentage released of naproxen from the three ophthalmic dosage forms after 7 hours were found to be in the following order; Drops>ocuserts>gels. These formulations exhibited the highest physical and chemical stability up to 6 months of storage at 25°C, 35°C and 45°C, except the formulae containing methylcellulose polymer, showed the least stable formulations. The drug content in the formulae containing methylcellulose was decreased about 10% after storage at different temperatures for 6 months

In-vitro evaluation of enrofloxacin ophthalmic preparation containing cyclodextrins

The effects of cyclodextrins [CyDs] [hydroxy propyl beta-cyclodextrin [HP-beta-CyD] and beta-cyclodextrin [beta-CyD]] on the solubility and release characteristics of enrofloxacin [Enr] from ophthalmic ointments and gels were investigated. The ophthalmic gels [sodium carboxymethyl cellulose [sod. CMC] and sodium alginate] and ointments [emulsion, absorption and water soluble bases] were prepared using 0.5% of the drug or equivalent amounts of its complexes with HP-beta-CyD or beta-CyD. The results revealed that the aqueous solubility of enrofloxacin was significantly increased by the formation of [1:2] inclusion complexes with CyDs. However, the solubility of enrofloxacin increased linearly as a function of HP-beta-CyD, followed by beta-CyD

Release characteristics of saluzide from suppository bases

Saluzide suppositories were prepared using Witepsols and polyethylene glycols [PEG] bases. The physicochemical and the release behaviour of drug from the prepared suppositories were investigated. The data of release of drug were analyzed according to order of kinetics. It was found that the release of saluzide from Witepsols was lower than that from PEG. In addition the rate of release was found to be diffusion controlled from the fatty bases. However, the first order kinetic fitted the release of drug from suppositories prepared using PEG

Effect of different polymers on the physico-chemical properties and stability of formulated chloramphenicol eye drops

The influence of different polymeric solutions as vehicles on the physical properties and stability of chloramphenicol were studied. Aqueous solution of polyvinylpyrrolidone, methyl cellulose and polyethy lene glycols were used as vehicles. The preparations showed good and stable characteristics for drug content, pH, viscosity and color changes. The theoretical analysis of the obtained results indicated that the drug is stable on storage at different temperatures

Effect of tween 80 and MYRJ 53 on the bioavailability and erosive activity of ketoprofen suppository

The presence of Tween 80 or Myrj 53 with ketoprofen in a suppository enhanced both the bioavailability and the rate of the drug released. The absorption of ketoprofen from Witepsol H[15] was enhanced by Tween 80 much more than Myrj 53, while both surfactants increased the maximum blood concentration of the drug in rabbits. The peak concentrations of ketoprofen were 28.3, 48.5 and 40.6 micro g/ml for Witepsol, Witepsol containing Tween 80 and Witepsol containing Myrj 53, respectively. The histological examination of the rectum of rabbits administered the tested suppositories showed that the drug has an irritation effect. However, this effect was minor in presence of Tween 80 or Myrj 53 with the drug