Effect of angiotensin converting enzyme inhibitor [captopril] on isolated rabbit aortic strip

This study demonstrated that captopril and ACE inhibitor induces an endothelium dependent relaxation in isolated rabbit aortic strip and the blood pressure lowering effect of angiotensin converting enzyme inhibitors was not based only on the inhibition of circulating and tissue angiotensin II formation. Prostanoids produced by ACE inhibitors [captopril] are involved in the dilatory mechanism