Pharmacological evaluation of muscle relaxant potency of mivacurium chloride against standard non-depolarizing muscle relaxant D. tubocurarin

The study was designed to evaluate potency of neuromuscular blocking activity of mivacurium chloride on the preparation of isolated frog's rectus abdominis muscle in contrast to that of the standard non - depolarizing muscle relaxant d- tubocurarin. The contractile response of the muscle was recorded in response to Acetylcholine [0.1 microg / ml] followed by addition of mivacurium to the bath Fluid and d- tubocurarin in a logarithmic increasing doses [1 mic/ ml- 16 mic/ml]. The percentage of inhibition by d-tubocurarin was more marked than that of mivacurium