Is There any Relationship between Age of Patients and Prostate Cancer Aggressiveness?

Introduction: Prostate cancer (Pca) is a disease thatcommonly afflicts elderly male population especially thoseof African descent. Diagnosis is usually confirmed bymicroscopic examination of prostate tissue sample. Gleasonsystem of grading Pca is widely adopted as a guide to selectingtreatment modalities as an independent prognostic factor. Inthis study, we aimed at evaluating the relationship betweenprostate volume (PV) and Gleason score (GS) in prostatecancer patients.Material and Methods: One hundred (100) male patients whowere evaluated for Pca between January 2014 and December2015 were studied. Information from their case notes wereretrieved and entered into spread sheets for analysis using thestatistical package for social sciences (SPSS) version 20.0.Results: The mean age of the patients was 67.88 + 8.83 yearsranging from 48 to 91 years. Mean prostate volume was 95.97+ 93.52mls, mean Gleason score was 7.89 + 1.20 while meanPSA of 56.33 + 38.99ng/ml was recorded. Most of the patientswere in their 8th decade of life. Majority of them had PV inexcess of 100mls and Gleason score of 9 was found in patientswith mean PV of 120.98 + 133.23mls.Conclusion: Our work documented mixed results of highgrade tumours observed in most patients, prostate sizenotwithstanding. This study predicts high grade disease in ourcohort of patients irrespective of prostate size

Correlation between prostate size and age of patients evaluated for symptomatic benign prostatic hyperplasia

Background: Benign prostatic hyperplasia (BPH) is the commonest cause of bladder outlet obstruction (BOO) in middle age and elderly men. Prostate size increases as a man ages. It has been documented that age and androgens are the greatest risk factors for BPH progression. The size of the prostate can predict the future need and outcome of BPH­related surgery. The aim of this study was to correlate prostatic size (volume) with age of patients evaluated for symptomatic BPH. Patients and method: This was a retrospective study of one hundred and ninety two (192) patients that were evaluated for BPH in two (2) urology centers in Nigeria between January 2018 and June 2019. Patient's bio-data, findings on history and physical examination, relevant laboratory and imaging studies, in particular, trans-rectal ultrasound reports of the prostate were collated and analyzed using the statistical package for social sciences (SPSS) version 20.0. Results: 192 men with a mean age of 64.23±9.47 years were evaluated. Majority of the patients presented in their 7th decade of life. Mean prostate volume was 67.59±45.70mls while mean prostate specific antigen (PSA) was 4.76±4.59ng/ml. Correlation between prostate volume and age was weak; r(192) = .172, P<0.05. Conclusion: Prostate size (volume) in our cohort of patients showed a weak correlation with age