ABSTRACT
Abstract Vegetative chronic genital herpes is an atypical presentation of herpes simplex 2 that it is usually seen in patients coinfected with human immunodeficiency virus. Clinically, it is characterized by extensive ulcers that evolve to chronification and hypertrophic pseudotumor forms. Antiviral drugs are recommended for the treatment, and acyclovir is the most used one. Foscarnet is the treatment of choice to resistant cases, although treatment failure has been reported. We report a male patient, previously diagnosed with human immunodeficiency virus who developed vegetative chronic genital herpes resistant to acyclovir and successfully treated with imiquimod.
Subject(s)
Humans , Male , Adult , Herpes Genitalis/drug therapy , Adjuvants, Immunologic/therapeutic use , AIDS-Related Opportunistic Infections/drug therapy , Imiquimod/therapeutic use , Herpes Genitalis/diagnosis , Adjuvants, Immunologic/administration & dosage , Chronic Disease , Treatment Outcome , Dose-Response Relationship, Drug , Imiquimod/administration & dosageABSTRACT
Abstract: Skin metastases are relatively rare and occur most often when the cancer is already advanced, invading other organs. As to location, they often seem to elect areas located close to the primary tumor, although distant sites, such as the scalp, may be affected with some frequency. We present a case of a 76-year-old woman with colon adenocarcinoma that had a single metastatic lesion on the scalp.
Subject(s)
Humans , Female , Aged , Scalp/pathology , Skin Neoplasms/secondary , Adenocarcinoma/secondary , Colonic Neoplasms/pathology , Head and Neck Neoplasms/secondary , Skin Neoplasms/pathology , Biopsy , Adenocarcinoma/pathology , Head and Neck Neoplasms/pathologyABSTRACT
Treatment with antithyroid drugs may be accompanied by side effects. We present a patient diagnosed with Grave's Disease who developed extensive vasculitis in the lower limbs during methimazole use. After suspension of the methimazole and the introduction of prednisone in immunesupressor doses the cutaneous lesions started to involute.
A terapêutica com drogas antitireoidianas pode ser acompanhada de efeitos colaterais. Apresentamos um caso de paciente com diagnóstico de Doença de Graves que na vigência da terapêutica com metimazol desenvolveu um quadro extenso de vasculite de membros inferiores. A partir da suspensão do metimazol e da introdução de prednisona em doses imunossupressoras as lesões cutâneas entraram em involução.
Subject(s)
Adult , Humans , Male , Antithyroid Agents/adverse effects , Graves Disease/drug therapy , Methimazole/adverse effects , Vasculitis, Leukocytoclastic, Cutaneous/chemically induced , Antineoplastic Agents, Hormonal/therapeutic use , Biopsy , Prednisone/therapeutic use , Treatment Outcome , Vasculitis, Leukocytoclastic, Cutaneous/pathologyABSTRACT
Calcinose cutânea é uma doença incomum, de fisiopatologia incerta e, muitas vezes, incapacitante. Caracteriza-se pela deposição de sais de cálcio na pele ou tecido subcutâneo. É classificada em quatro subtipos: metastática, distrófica, idiopática e iatrogênica. Pode ser vista em várias doenças sistêmicas como hiperparatireoidismo e hipervitaminose D, ocorrendo com maior frequência na dermatomiosite, esclerodermia e síndromes overlap, sendo uma complicação infrequente no lúpus eritematoso sistêmico. O manejo das complicações secundárias, assim como o sucesso terapêutico, constituem desafios constantes no seguimento destes casos.
Calcinosis cutis is an uncommon disease of unclear pathophysiology that is often disabling. It is characterized by the formation of calcium deposits in the skin or subcutaneous tissue. It is classified into four subtypes: dystrophic, metastatic, idiopathic or iatrogenic. It may be seen in a variety of systemic diseases such as hyperparathyroidism and hypervitaminosis D, but is most commonly found in dermatomyositis, scleroderma and overlap syndromes and is a rare complication of systemic lupus erythematosus. The management of secondary complications and the success of therapy are constant challenges in the follow-up of these cases.
Subject(s)
Adult , Female , Humans , Calcinosis/etiology , Lupus Erythematosus, Systemic/complications , Skin Diseases/etiology , Calcinosis/pathology , Follow-Up Studies , Skin Diseases/pathologyABSTRACT
A bleomicina é agente quimioterápico usado no tratamento de diferentes neoplasias. Apresenta vários efeitos colaterais, sendo um deles a hiperpigmentação cutânea de aspecto flagelado, considerada específica dessa droga. Relatam-se dois casos de dermatite flagelada induzida pela bleomicina. Discutem-se os aspectos clínicos e etiopatogênicos em breve revisão bibliográfica.
ABSTRACT
18 girls from an orphanage (Orfanato Santo Antônio) in Niterói presented tinea capitis due to Trichophyton tonsurans (15 cases-83.3% ) and Microsporum canis (3 cases-26.7% ). Comments are made about clinical, mycological and therapeutic aspects of this microepidemic
Subject(s)
Humans , Female , Dermatomycoses/epidemiology , Disease Outbreaks/statistics & numerical data , Microsporum , Tinea Capitis/epidemiology , Brazil/epidemiology , Child , Dermatomycoses/diagnosis , Dermatomycoses/drug therapy , Griseofulvin/administration & dosage , Microsporum/isolation & purification , Remission Induction , Tinea Capitis/diagnosis , Tinea Capitis/drug therapy , Trichophyton/isolation & purificationABSTRACT
Apresenta-se um caso de botriomicose tegumentar em paciente jovem com testes sugestivos de imunidade tardia alterada. O diagnóstico baseou-se no exame da secreçäo purulenta, que evidenciou gräos, e no exame histopatológico, que revelou bactérias no interior dos mesmos. Foi isolado Staphylococcus aureus em cultura, obtendo-se melhora do quadro com drenagem cirúrgica e antibioticoterapia. Os achados imunológicos deste caso parecem apoiar a hipótese de que possam haver fatores imunitários implicados na patogênese desta infecçäo