ABSTRACT
Objective: To evaluate the relationship between estrogen and progesterone receptor status and the presence of diabetes mellitus, hypertension, obesity or dyslipidemia Design: Retrospective study Setting: Department of Oncology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Subjects: A hundred and twelve Saudi patients diagnosed with breast cancer, admitted to King Khalid University Hospital [KKUH] between 2000 and 2006 Intervention: Fine needle or true cut biopsy Main outcome measure: Association between tumor receptor status and the presence of comorbidity
Results: There was no relationship between estrogen receptors and progesterone receptors expression and the presence of diabetes mellitus, dyslipidemia, hypertension or obesity. Hypertension was associated with HER2/neu positivity [p = 0.045, OR = 2.817, CI 95% [1.023 - 7.754]]. Hypertensive patients were also found to present with earlier clinical T-stages [p = 0.045]
Conclusion: Expression of estrogen and progesterone receptors was not affected by the presence of diabetes mellitus, dyslipidemia, hypertension or obesity. However, our findings suggest that hypertension is related to HER2/neu positivity. Hypertensives were also more likely to present with earlier clinical T stages than nonhypertensives
ABSTRACT
Systemic lupus erythematosus [SLE] is associated with major gastrointestinal complications due to radiotherapy. A patient with active SLE and grade 4 nephropathy presented with inoperable advanced cancer of the cervix which proved to be contraindicated for chemotherapy. The patient was treated with intensity-modulated radiotherapy technique [IMRT]. The patient, however, did not experience severe radiotherapy-related complications as expected with conventional techniques of radiotherapy. The tolerance of SLE patients to radiotherapy can thus be achieved by proper delivery of radiation and the sparing of normal tissues by IMRT although further confirmatory studies are required