Antimicrobial and antitumor activities of three new antibiotics and their effects on protein and nucleic acids synthesis

The anti-microbial activity, toxicity and antitumor activity of three new antibiotics were investigated in relation to their effects on protein, DNA and RNA synthesis of some gram positive and gram negative bacteria. The results indicated that one antibiotic demethyltetracycline did not show any toxic effect on normal Swiss albino mice at a concentration up to 500 mg/kg body weight, meanwhile it exhibited an in vivo antitumor effect against Ehrlich ascites tumor. However, granaticin and caeseorhodomycin showed a slight toxicity [10%] to normal Swiss albino mice at a concentration of 450 mg/kg body weight, but they did not show a significant antitumor effect against Ehrlich ascites tumor. The three tested antibiotics acted as inhibitors to protein and DNA synthesis, but they had no marked effect on RNA synthesis

Effect of foliar application of GA and Zn on ocimum basilicum L grown in different soil types

Pot experiments were carried out to investigate the effect of sprays with GA [100 ppm], Zn at two doses [75 and 100 ppm] and a combination of both on Ocimum basilicum plants grown in two types of soil. The results revealed that soil type had no effect on plant height, branches number and fresh weight of the herb at the first and second cut, meanwhile, the third cut of the basil plants grown in sandy loamy soil surpassed the corresponding grown in calcareous soil. GA-treatment increased growth characters and carbohydrate content in both soils but oil content only in sandy loamy one. Combined treatments of GA and Zn gave the highest values of herb yield, carbohydrate and oil content compared with other treatments. Data obtained from interaction treatments showed that the combination between GA and Zn [75 ppm] gave the best results under calcareous conditions