ABSTRACT
Background: The main part of ovary is consisted of follicles which certain drugs may cause change in them
Objectives: The purpose of this study was to investigate the effects of Methylphenidate on ovarian follicle of mice, treated by Ritalin before puberty
Methods: 40 immature female mice at 3 weeks of age were divided into 4 groups, consisting of one control and 3 experimental groups. The experimental groups were gavaged by 2, 5 and 10 mg/kg methylphenidate respectively and the control group received only distilled water with the same method for 60 days. At the end of the experiment, the mice were weighed and then the serum levels of FSH and LH were assessed and structural changes of ovarian follicles and corpora lutea were studied
Results: The mean difference of body weight in experimental groups compared with the control group which showed a significant reduction [p<0.05]. In experimental groups compared with the control group, a significant reduction in pre enteral, enteral follicles, corpora lutea and a significant increase in atretic follicles were observed [p<0.05]
Conclusions: Ritalin intake for a long period may increase the number of atretic follicles and decrease corpora lutea, so subsequently results in reduction of the growth of follicles and oocytes as well as inducing the atypical appearance of the cells in the luteinized cells
ABSTRACT
To evaluate the etiology of cataract and prevalence and correlation of risk factors with various types of cataract. Among the patients who underwent cataract surgery in Labafinejad Hospital in 2004, 400 patients were chosen by a systemic sampling method. Information were collected from the patients' records and recorded in a check list. Senile and congenital types of cataract were the most prevalent in the sample. There was a correlation between age, mean age, sex, type of involvement and type of cataract. Among systemic diseases, hypertension was the most common [35.5%], followed by diabetes mellitus [22%]. In slit lamp examination, of congenital cases, the most common opacity was lamellar type and in other types of cataract, mixed opacity was the most common type. In this study the proportion of male cases was greater than that reported in other studies. Meanwhile, 65.5% of the patients were under the age of 70, which shows the need for evaluation of the relatively low age of onset in Iran