ABSTRACT
Changes in body fat distribution during menopause lead to increasing risk of cardiac and metabolic diseases. Considering the importance of predicting of cardiovascular diseases using related anthropometric indices, the aim of this study was to determine the correlation of waist circumference[WC], BMI and Conicity with cardiovascular risk factors [serum glucose, insulin[diabetes], blood pressure[BP] and dyslipidaemia]. In a cross-sectional study, 250 non-smoking postmenopausal women, with BMI<30 were randomly selected. We measured WC, BMI and conicity and a 3 day food dietary recall and a food frequency questionnaire were completed for each participant. Fasting serum glucose, triglycerides, HDL-C, LDL-C and insulin were measured. There were significant correlations between WC and systolic BP[r=0.255, p=0.002], WC and conicity [r=0.67,p=0.0001], BMI and conicity[r=0.31, p=0.0001], conicity and systolic BP[r=0.31, p=0.009] and BMI systolic BP[r=0.21,p=0.009]. There were also significant correlations between systolic BP and diastolic BP[p=0.002], serum insulin and systolic BP[r=0.21,p=0.008] and serum total cholesterol with systolic BP[r=0.2,p=0.13]. Waist circumference was significantly associated with systolic BP and diabetes, BMI had a significant association with systolic BP and Conicity was significantly associated with systolic BP, serum triglycerides and glucose, but not with diabetes
ABSTRACT
Background and purpose: Vitamin D is an antiproliferative agent against cancer cells and regulates cell differentiation. It acts via Vitamin D Receptor [VDR]. The VDR gene contains a Start Colon Polymorphism [SCP] that can be detected with the restriction enzyme Fok I. Previous studies report an association of SCP and some diseases and some suggest that this polymorphism alters VDR function. As no studies so far have reported the association between Fok I genotype in Thyroid cancer, this study is intended to determine the association of Fok I polymorphism of VDR with thyroid cancer risks in Iranian population
Methods and Materials: 58 patients with papillary carcinoma, 13 patients with follicular carcinoma and 82 controls participated in a case-control study. A PCR-RFLP method used to determine VDR gene polymorphism in start codon characterized by the restriction enzyme Fok I. 95% confidence intervals and odds ratio were calculated for testing the relationship between Fok I polymorphism and thyroid cancer
Results: The odds ratio for the Fok I polymorphism on thyroid cancer was 0.39 [95% CI, 0.12-1.27] witch signifies no relationship between this polymorphism and the ris of thyroid cancer
Conclusion: As no relationship was found between this polymorphism and thyroid cancer, other genetic or environmental factors may be considered in thyroid cancer