[Comparison between efficacy of ciprofioxacin-doxycycline and rifampin-doxycycline regimens in treatment of brucellosis]

Brucellosis is an endemic disease in Iran that has a worldwide spread and is associated with chronic disabilities in humans. Combination therapy of brucellosis leads to recovery of symptoms, shortening of the symptomatic intervals, and decrease in the rate of relapse and drug resistance. Considering the use of rifampin in the treatment of tuberculosis, and the necessity for an alternative treatment in regions endemic for both tuberculosis and brucellosis, in this study we compared the efficiency of the WHO's standard regimen of rifampin-doxycycline [RD] versus ciprofloxacin-doxycycline [CD] for the treatment of brucellosis. This randomized controlled trial was performed on 90 patients, affected with brucellosis, who were referred to the Infectious Disease Clinics at Arak University of medical sciences. The patients were randomly divided into two groups: the DR group, received 100 mg of Doxycycline twice a day and 300 mg of rifampin Bid daily for eight weeks; and the CD group, received 100 mg of doxycycline plus 500 mg of ciprofloxacin twice a day for eight weeks. The patients were analyzed for the relief of symptoms, drug side effects, and laboratory findings during the treatment. In this study, the rate of symptom relief and laboratory findings in both groups were similar. The relief of symptoms was seen in 93.2% and 83.9% of the patients for the DR and CD groups, respectively [P=0.182]. The side effects of the drug were not significant in either groups, with no significant difference, and did not lead to discontinuation of the therapy. Due to the similar efficacy of CD and DR regimens in the treatment of brucellosis and considering the usage of rifampin in regions with high prevalence of tuberclusis, the CD regimen is recommended as an appropriate treatment

[Brucellaspondylodiscitis and paravertebral abscess with negative serology: a case report]

Brucellosis is a common zoonosis which still remains as a major health problem in certain parts of the world. Osteoarticular involvement is the most frequent complication of brucellosis, in which the diagnosis of brucellarspondylodiscitis is often difficult, since the clinical presentation may be obscured by many other conditions. We report an uncommon case of spondylodiscitis with paravertebral abscess. The diagnosis was established by using magnetic resonance imaging that was also confirmed by positive culture. This report describes a case of a 42-year-old woman. Serodiagnosis for brucella carried out at the onset of symptoms 4 months and 1.5 months before admission were negative. When the patient was admitted to our hospital, laboratory tests showed negative agglutination, and ELISA test for brucella and magnetic resonance imaging confirmed the presence of a paravertebral abscess around the affected disc and tissue edema. Culture of needle aspiration of abscess tissue was positive for brucella melitensis

Effect of metronidazole on amount of blood's lipids of hyperlipidemia people

Metronidazole has antibacterial and antiparasitic action. Therefore it can use for treatment inflammatory diseases as Crohn. The effect of metronidazole on human's blood lipids to reducing levels of LDL and VLDL and increasing level of HDL is under investigation. Target of this research is consideration effect of metronidazole on hyperlipidemia case of death such as coronary artry disrase. This study is a triple blind clinical trial was done on 100 voluntaries between 25-65 years old. with hyperlipidemia. Samples divided in two equal groups. The first group received metronidazol, 500mg, BID, for 10 days, and control group received placebo with the same dose. Lipids of serum were measured before and after using drugs, then data analyzed by SPSS software. In metronidazol group amount of total cholesterol, LDL and Triglyceride were significantly less than placebo group. HDL's amount in metronidazole group was significantly more than placebo group. Significant effect of metronidazole on reducing harmful blood lipids and increasing useful blood lipids. It can be suggested a probable candidate in treatment of hyperlipidemia. Maybe it can use with this application. Although it needs to more study by meta analysis to validate this effect

[ effect of single-dose therapy compared with seven-day therapy of ciprofloxacin in woman suffering from lower urinary tract infection [UTI]]

Lower urinary tract infection is one of the most common infections among young women. The high prevalence of this infection necessitates the administration of appropriate antibiotic and minimizing the treatment period. In this study we examined and compared the effect of single-dose therapy of ciprofloxacin with seven-day therapy in women with lower UTI. The study cases comprised of 140 women aged 13-25 years with uncomplicated lower UTI who referred to Vali-Asr hospital in Arak. The patients were randomly assigned into two groups of 70. One group received a single-dose ciprofloxacin [1000 mg] while the other group received a seven-day ciprofloxacin [250 mg twice daily]. Urine culture was performed for all the patients three times. In case of primary positive culture the patient would enter the study, and the second culture was carried out to investigate the response to the treatment, whereas the third culture was carried out to study the recurrence. Finally, the results of the two groups were analyzed. Out of 140 patients participating in the study, 23 cases did not respond to the treatment. In the final assessment 14 non-responsive patients belonged to single-dose group while 9 patients were in seven-day therapy group. The research findings showed that there was no significant difference between the two groups [p=0.183] in response to the drug and recurrence. This indicates the equal efficacy of single-dose treatment and one-weak therapy of ciprofloxacin in women with lower UTI