ABSTRACT
In regard to the limited studies about the effect of creatine on exercise-induced inflammatory responses, the present study was conducted to identify the effect of creatine monohydrate loading on response of serum C-reactive protein [CRP], interleukin-6 [IL-6] and peripheral blood leucocytes following one bout downhill running in male mountain climbers. Twenty volunteer young male mountain climbers [aged 24.5 +/- 1.82 year, fat = 10.42 +/- 1.96%, and VO2max = 53.56 +/- 2.36 ml/kg/min] in a quasi-experimental, randomized and double-blind design were allocated equally into supplement and placebo groups. After five consecutive days supplementation [0.3 g/kg body weight/day creatine monohydrate or dextrose], all subjects were participated in one bout downhill running protocol on a treadmill [-15% incline] for 30 minutes with 65% heart rate reserve [HRR]. Changes in inflammatory indices were determined in four phases [baseline, after the supplement period, immediately and 24 hours after the exercise]. Data were analyzed by repeated measure ANOVA, Bonferroni and independent t-test at alpha