Comparative screening of chlamydia trachomatis infection in women population in Tehran, Iran

There are more than 30 different sexually transmissible agents while the most common one is Chlamydia trachomatis. In this prospective study, we decided to compare the prevalence of infection in symptomatic and asymptomatic females. Two hundred sixty urine samples of women in two groups [symptomatic and asymptomatic] were collected from patients attending Mehrad Hospital in Tehran, Iran and tested by polymerase chain reaction. Thirty nine women in both groups were infected [14.99%], while 27/130 subjects were in symptomatic group [20.76%], compared with 12/130 person in asymptomatic group [9.23%]. No statistically significant difference was found between two groups. Data analysis showed infection with C. trachomatis in symptomatic women to be significantly associated with history of sexually transmitted infections, white blood cells in urine and epithelial cells in urine. The present study recommends that targeted screening programs in high risk sexually active women [like as individuals who had a history of STIs] are needed as part of case-finding strategies and treatment

[ evaluation of antifungal activity of titanium dioxide nanoparticles and ethylene diamine tetra acetic acid on growth inhibition of standard strain of Candida albicans]

In recent years, the incidence of opportunistic fungi has shown a marked increase. Infection caused by common pathogenic fungi is a significant health problem in immune compromised hosts. The present study evaluated antifungal activity of Titanum dioxide nanoparticles and Ethylene diamine Tetra-acetic Acid against Candida albicans as self-cleaning agent by standard micro dilution test. The present study was conducted at the Medical University of Tarbiyat Modares in 2009. TiO2 nanoparticles were obtained through the hydrolysis of TiCl4 [Titanium tetrachloride]. Size and type of these nanoparticles were characterized by scanning electron microscopy [SEM] and X-Ray-Diffraction [XRD]. Afterwards, the Minimum Inhibitory Concentration [MIC] and Minimal Fungicide Concentration [MFC] test for TiO2 and EDTA were performed. Concentration of synthesized TiO2 was 7.03 mg/ml and 5.63 x 10[20] particles/ml. evaluation of morphology and diameter of the TiO2 nanoparticles with SEM showed that nanoparticles were spherical with diameter between 40-65 nm. MIC50 of 2.2, 1.24 and 0.125 micro g/ml respectively. MIC90 and MFC of TiO2, EDTA and fluconazole were 3.51, 2.48, 0.5 micro g/ml and 4.06, 3.1, 1 micro g/ml respectively. In the present study, using of synthesized TiO2 nanoparticles with chemical method showed a suitable activity against Candida in comparison with Fluconzaole. Thus it might represent a good candidates in elimination of Candida in medical from medical devices

[Evaluation of steroid hormone receptors expression in nasopharyngeal angiofibroma]

Juvenile nasopharyngeal angiofibroma [JNA] is uncommon benign tumor that occur exclusively in the lateral portion of nasopharynx of adolescent boys. Sex selectivity at JNA may suggest relation its pathogenesis to hormonal changes of pubertal period .Some reports showed indirect evidence for the presence of androgen [AR], estrogen [ER], and progesterone [PR] receptors, in these tumors. The goal of the current study was to show direct evidence of sex hormone receptor expression in angiofibroma with use of immunohistochemical technique and to document which cells population express these receptors. 30 cases of juvenile nasopharyngeal angiofibroma and equal number of normal nasopharyngeal tissue were selected from archive of pathology department of mashhad Ghaem hospital then standard Immunohistochemical technique was performed in theirs paraffin blocks with ER, PR and AR immunohistochemical markers. Nuclear immunoreactivity was examined in stromal and endothelial cells of each case then these results analyzed with Pearson Chi-Square test. AR, and ER expression was seen in angiofibroma in 80% and 26.7% and in normal tissue 26.7% and 10% of cases respectively. We did not find any PR expression in both normal and tumoral tissue. Differences between AR expression in tumoral and normal tissue was meaningful but this correlation do not true about ER and PR. our results maybe agree with the significant role of androgen receptors in the pathogenesis of angiofibroma and benefit of antiandrongeic drugs for therapeutic response

Papillary thyroid carcinoma in Mashhad

Thyroid cancer is the most common endocrine malignancy. This study surveys the pathologic characteristics of thyroid cancer in Mashhad and study of papillary carcinoma in more detail. In this retrospective study, 108 out of 197 cases of thyroid cancer were papillary in type [55%], with female to male ratio of 1.91 which is lower than current reports. The age at the time of diagnosis ranged from five to 78. Mean age for females was 36 and for males was 38.45 years. We hope that this study will stimulate physicians to reevaluate their thoughts about thyroid cancer and try to recognize such patients at an earlier stage in the course of their disease