ABSTRACT
Visual sciences have been progressing quickly in recent decades through globalization phenomenon. An enormous change has taken place in ocular health issues, however, there are various problems facing ophthalmic public health worldwide. In the previous years, the World Health Organization and the International Agency for the Prevention of Blindness in partnership launched the global initiative to eradicate avoidable blindness by the year 2020, VISION 2020 the Right to Sight. It has concentrated on the prevention of blindness disability and recognized a health issue-sight as a human right. In view of challenges ahead of visual sciences, close collaboration between international agencies at the global level to implement new strategies and monitor the progress will be mandatory. In these circumstances non-governmental organizations should not be neglected. World Sight Day 2012 would be a great opportunity to be a focus on importance of visual impairment as an important public health issue and discovering new challenges ahead
ABSTRACT
The present study was undertaken to investigate the correlation of Epidermal Growth Factor Receptor [EGFR] expression with grade of Transitional Cell Carcinoma [TCC]. Tumor samples of 75 patients from Mostafa Khomaini Hospital with Transitional Cell Carcinoma of the bladder were analyzed by immunohistochemistry for expression of EGFR. In this context, we assigned the bladder tumors a grade according WHO classification. Results analyzed for possible correlation with the expression status of the Epidermal Growth Factor Receptor [EGFR]. This cross-sectional study showed that all grades of Transitional Cell Carcinoma expressed EGFR, and 14 cases were EMP [18.9%] which 10 cases among them had negative cells according EGFR point of view [71.4%] and 4 cases had reported positive [28.6%]. Thirty five cases were low grade [46.7%] which 18 cases among them had reported negative cells [51.4%] and 17 cases had positive cells [48.6%]. Twenty six cases were high grade [34.7%] that 9 cases among them had reported negative cells [34.6%]. Seventeen cases had positive cells [65.4%]. Mann-Witney test showed the relation between grade and expression of EGFR [P<0.05]. This study showed that expression of EGFR is correlated with grade of tumor