[Survey the changes of thyroid functional tests in patients with liver cirrhosis due to hepatitis B and C and correlation of thyroid hormone levels with severity of liver dysfunction]

The liver played an important role in the metabolism of thyroid hormones and was involved in their conjugation, excretion and peripheral deiodination in synthesizing Thyroid Binding Globulin [TBG]. Thus liver dysfunction can be influenced thyroid function. Determine the changes of thyroid functional tests in patients with liver cirrhosis due to hepatitis B and C and correlation of thyroid hormone levels with severity of liver dysfunction. Sixty Four Cirrhotic patients due to hepatitis B and C referring to Razi hospital were studied during 2007-2009 years. Data were collected by prepared questionnaire. Thyroid hormone levels were measured in a unit laboratory. Liver dysfunction was scored by MELD and child pugh scoring systems. Mann-Whitney U, chi square and kruskal wallis test were used for measuring severity of liver dysfunction. Among 64 patients, [42 patients were male and 22 patients were female]. Mean age of patients was 55.03 +/- 12.05. Level of TT3 TT4 and FT3 had decreased in the majority of patients, TT3, TT4 and FT3 levels. There was a correlation between level of TT3 and severity of liver dysfunction base on Child score [p=0.0001] and MELD [p=0.02].There was a reciprocal correlation between TT3 level and probability of the history of digestive systems bleedings, Ascites and encephalopathy [P=0.01, P=0.011, P=0.009] .It means that when TT3 level was low probability of this complication was high. This study showed that liver disease is accompanied by changes in thyroid hormone levels specially decrease the level of TT3, TT4, FT3 and it is indicated that TT3 level can be used as liver function index in cirrhotic patients due to hepatitis B and C

[Anxiety-depressive disorders among irritable bowel syndrome [IBS] patients]

Psychiatric disorders are common in Irritable Bowel Syndrome [IBS] patients. Prevalence of psychiatric disorders varies in IBS patients in different societies. To determine the prevalence of psychiatric disorders [anxiety-depression] in IBS patients in Rasht. In this cross-sectional study, 256 IBS patients were selected [using criteria of Rome III] and evaluated for psychiatric disorders. In the first phase, subjects were screened by GHQ28. In the second phase, those patients who had scores equal or more than 23 were assessed through semi-structured psychiatric interview. Socio-demographic variables including age, gender, marital status, educational level and occupation, were recorded as well. P-values less than 0.05 were considered statistically significant. Among 256 subjects 30 patients [11.7%] had no significant psychiatric symptoms and 226 subjects [83 male, 143 female] suffered from some degrees of psychiatric problems. After performing semi-structured psychiatric interview; 190 subjects [74.2%] had anxiety-depressive problems [89 patients were suffered from pure anxiety disorders, 41 patients suffered from depressive disorders and 60 patients had co-morbid anxiety-depressive disorders]. In anxiety disorders; generalized anxiety disorder [53.7%] and in depressive disorders; dysthymia [53.5%] had the most frequencies, 53.7% and 53.5% respectively. In comparisone of anxiety-depressive subjects [190 persons] and normal subjects [66 persons], there was a significant statistical differences between the gender [P=0.019], occupation [P=0.002] and intensity of IBS [P<0.001]. Although, further studies are needed to determine the relations of demographic variables and types of IBS with psychiatric disorders, it seems to more attention to the psychiatric disorders of some specific patients suffering from IBS is helpful to their treatment

[Determine the attitude about community based participatory research in people residing in Ali Abad]

Introduction: Participatory research as performing research by involving all people, need to public participation, so determining the attitude of people toward this topic is important

Objective: Determine the attitude about Community Based Participatory Research in People Residing in Ali Abad

Materials and Methods: This descriptive cross sectional study was performed on 178 people residing in Aliabad with a convenient sampling method. A structured questionnaire comprised of attitude statement and demographic characteristics was used for data collection and completed self administered by participants. The validity of attitude statements was determined by faculty members and reliability was measured by Cronbach's alpha greater than 0.7. T-test was applied for data analysis using SPSS program

Results: The mean attitude score was 45.56 [95% CI: 44.74-46.38]. Furthermore the mean attitude in empowering category with 20 maximum score was 10.77 [95% CI: 10.77-11.48], removing community problem with 15 maximum score was 9.11 [95% CI; 8.84-9.38], community participation with 25 maximum score was 16.12 [95% CI; 15.74-14.49] and community confidence with 15 maximum score was 9.0[8.64-9.37]. Participant attitude toward community based participatory research was statistical significantly associated with respondents membership in population research center [P<0.05]

Conclusion: The most important factor in successfully administrating community base programs is the community participation. The findings of this study indicate the importance of community based participatory research for community