[ impact of chronic hemodialysis on QT dispersion, corrected QT dispersion and maximum QT-dispersion]

Sudden cardiac death is common in patients on hemodialysis and may occur in the immediate postdialysis period when ventricular premature complexes are common. QT dispersion, reflecting hetovogelity in ventricle repolarization, has been used for predicting patients with risk of malignant arrhythmia and sudden death. The purpose of the study was to assess the effect of hemodialysis on QT dispersion [QTd], corrected QT dispersion [QTcd] and maximum QTc [QTcMax] in chronic hemodialysis patients. In this descriptive-analytic study, data of 48 patients [30 male and 18 female patients with mean age, 43 +/- 16 yr] on chronic hemodialysis were studied. 12 lead ECG were recorded 5-10 minutes before and after hemodialysis in a standard setting and Na +, K+, Ca+ +, Po4 and Mg++ levels were also determined pre and post hemodialysis. During hemodialysis, no drug therapy was used except isotonic and hypertonic NaCl influsions and sodium heparin. The maintenance drug therapy including digitalis, antihypertensive, antianginal, and beta blocking agents was not changed. The data were analyzed using SPSS software. The maximal QTd interval changed significantly from 434 +/- 12.8 ms to 443 +/- 21.33 ms [P<0.001]. The QTd increased significantly from 55.87 +/- 7.5 ms to 61.27 +/- 9.09 ms [P<0.001] and QTcd from 61.18 +/- 7.43ms to 68.79 +/- 10.32ms [P<0.001]. 33.33% of the patients before and 47.90% after hemodialysis had QTcMax more than 440 ms. Hemodialysis increases the QTd, QTcd and QTcMax in patients with end-stage renal failure. Thus it is likely that heterogeneity of regional ventricular repolarization increases during hemodialysis

[ effect of using diazepam on the memory function of the patients undergoing general anesthesia]

Introduction and Objective: in order to decrease the worries and anxieties in the patients undergoing general anesthesia before and after the surgery, the specialists in this field use benzodia zepins drugs specially diazepam. This was because these drugs have relaxation and forgetfulness effects

Materials and Methods: this study is a clinical trial done in a randomized double-blind form. In order to determine the effects of diazepam on memory power, the Wechsler test was applied on 40 patients [37 male, 3 female] referring to the Amir-AL-Momenin [NAHAJA] hospital in Bushehr city during the year 1382

Results: the results showed that there was no difference between the average total marks in case and control groups before and after using anesthesia. This means the drug diazepam had no effect on memory power as a whole. There was significant difference between pre and post -anesthesia scores in recall, number repetition and logic memories in case group, but there was a significant difference only for recall memory in control group[p<0/05]

Conclusion: in this investigation it was found out that the drug diazepam has no effect on memory function and the anesthesia especially forgetfulness which has been mentioned in the medical test may not be so correct and needs more investigation